Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels

Trivia Frazier, Andrea Alarcon, Xiying Wu, Omair A. Mohiuddin, Jessica M. Motherwell, Anders H. Carlsson, Robert J. Christy, Judson V. Edwards, Robert T. Mackin, Nicolette Prevost, Elena Gloster, Qiang Zhang, Guangdi Wang, Daniel J. Hayes, Jeffrey M. Gimble

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose‐, blood‐, and cellulose‐derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.

Original languageEnglish (US)
Article number1373
Pages (from-to)1-21
Number of pages21
JournalBiomolecules
Volume10
Issue number10
DOIs
StatePublished - Oct 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels'. Together they form a unique fingerprint.

Cite this