Clinical trials of an intravenous oxygenator in patients with adult respiratory distress syndrome

Kane High, M. T. Snider, R. Richard, G. B. Russell, J. K. Stene, David Campbell, T. X. Aufiero, G. A. Thieme

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

In patients with severe adult respiratory distress syndrome, mechanical ventilation may not be able to ensure gas exchange sufficient to sustain life. We report the use of an intravenous oxygenator (IVOX) in five patients who were suffering from severe adult respiratory distress syndrome as a result of aspiration, fat embolism, or pneumonia. IVOX was used in an attempt to provide supplemental transfer of CO2 and O2 and thereby reduce O2 toxicity and barotrauma. All patients were tracheally intubated, sedated, and chemically paralyzed and had a Pa(O2) < 60 mmHg when the lungs were ventilated with an FI(O2) = 1.0 and a positive end expiratory pressure of ≥5 cmH2O. The right common femoral vein was located surgically, and the patient was systemically anticoagulated with heparin. A hollow introducer tube was inserted into the right common femoral vein, and the furled IVOX was passed into the inferior vena cava and advanced until the tip was in the lower portion of the superior vena cava. IVOX use ranged from 2 h to 4 days. In this group of patients, IVOX gas exchange ranged from 21 to 87 ml x min- 1 of CO2 and from 28 to 85 ml x min-1 of O2. One of the five patients survived and was discharged from the hospital. The IVOX transferred up to 28% of metabolic gas-exchange requirements. One patient with a small vena cava showed signs of caval obstruction. Three other patients demonstrated signs of a septic syndrome after the device was inserted. In the patient who survived, the IVOX did not appear to play a significant role in his outcome. Clinical considerations and factors limiting the use of the IVOX are presented. Because of gas-exchange limitations, design alterations to the IVOX may be required.

Original languageEnglish (US)
Pages (from-to)856-863
Number of pages8
JournalAnesthesiology
Volume77
Issue number5
DOIs
Publication statusPublished - Nov 24 1992

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

High, K., Snider, M. T., Richard, R., Russell, G. B., Stene, J. K., Campbell, D., ... Thieme, G. A. (1992). Clinical trials of an intravenous oxygenator in patients with adult respiratory distress syndrome. Anesthesiology, 77(5), 856-863. https://doi.org/10.1097/00000542-199211000-00004