Clinical utility of extracorporeal cytokine hemoadsorption therapy: A literature review

Anthony Bonavia, Andrew Groff, Kunal Karamchandani, Kai Singbartl

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.

Original languageEnglish (US)
Pages (from-to)337-349
Number of pages13
JournalBlood Purification
Volume46
Issue number4
DOIs
StatePublished - Oct 1 2018

Fingerprint

Cytokines
Sepsis
Therapeutics
Technology
Septic Shock
Critical Illness
Anti-Inflammatory Agents
Morbidity
Mortality
Infection

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

@article{5b246fd356d540c2b5310e8085f3f385,
title = "Clinical utility of extracorporeal cytokine hemoadsorption therapy: A literature review",
abstract = "Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.",
author = "Anthony Bonavia and Andrew Groff and Kunal Karamchandani and Kai Singbartl",
year = "2018",
month = "10",
day = "1",
doi = "10.1159/000492379",
language = "English (US)",
volume = "46",
pages = "337--349",
journal = "Blood Purification",
issn = "0253-5068",
publisher = "S. Karger AG",
number = "4",

}

Clinical utility of extracorporeal cytokine hemoadsorption therapy : A literature review. / Bonavia, Anthony; Groff, Andrew; Karamchandani, Kunal; Singbartl, Kai.

In: Blood Purification, Vol. 46, No. 4, 01.10.2018, p. 337-349.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Clinical utility of extracorporeal cytokine hemoadsorption therapy

T2 - A literature review

AU - Bonavia, Anthony

AU - Groff, Andrew

AU - Karamchandani, Kunal

AU - Singbartl, Kai

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.

AB - Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.

UR - http://www.scopus.com/inward/record.url?scp=85053036995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053036995&partnerID=8YFLogxK

U2 - 10.1159/000492379

DO - 10.1159/000492379

M3 - Review article

C2 - 30176653

AN - SCOPUS:85053036995

VL - 46

SP - 337

EP - 349

JO - Blood Purification

JF - Blood Purification

SN - 0253-5068

IS - 4

ER -