Clinical utility of extracorporeal cytokine hemoadsorption therapy: A literature review

Anthony Bonavia, Andrew Groff, Kunal Karamchandani, Kai Singbartl

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.

Original languageEnglish (US)
Pages (from-to)337-349
Number of pages13
JournalBlood Purification
Volume46
Issue number4
DOIs
StatePublished - Oct 1 2018

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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