We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5′- and 3′-untranslated regions are also conserved between species.
All Science Journal Classification (ASJC) codes
- Structural Biology