Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Harry Mellor, Kevin M. Flowers, Scot R. Kimball, Leonard S. Jefferson

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5′- and 3′-untranslated regions are also conserved between species.

Original languageEnglish (US)
Pages (from-to)693-696
Number of pages4
JournalBBA - Gene Structure and Expression
Volume1219
Issue number3
DOIs
StatePublished - Nov 22 1994

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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