Closed-loop controlled noninvasive ultrasonic glucose sensing and insulin delivery

Eun Joo Park, Jacob Robert Werner, Devina Jaiswal, Nadine Barrie Smith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

To prevent complications in diabetes, the proper management of blood glucose levels is essential. Previously, ultrasonic transdermal methods using a light-weight cymbal transducer array has been studied for noninvasive methods of insulin delivery for Type-1 diabetes and glucose level monitoring. In this study, the ultrasound systems of insulin delivery and glucose sensing have been combined by a feedback controller. This study was designed to show the feasibility of the feedback controlled ultrasound system for the noninvasive glucose control. For perspective human application, in vivo experiments were performed on large animals that have a similar size to humans. Four in vivo experiments were performed using about 200 lbs pigs. The cymbal array of 3×3 pattern has been used for insulin delivery at 30 kHz with the spatial-peak temporal-peak intensity (Isptp) of 100mW/cm2. For glucose sensing, a 2×2 array was operated at 20 kHz with I sptp=100mW/cm2. Based on the glucose level determined by biosensors after the ultrasound exposure, the ultrasound system for the insulin delivery was automatically operated. The glucose level of 115 mg/dl was set as a reference value for operating the insulin delivery system. For comparison, the glucose levels of blood samples collected from the ear vein were measured by a commercial glucose meter. Using the ultrasound system operated by the close-loop, feed-back controller, the glucose levels of four pigs were determined every 20 minutes and continuously controlled for 120 minutes. In comparison to the commercial glucose meter, the glucose levels determined by the biosensor were slightly higher. The results of in vivo experiments indicate the feasibility of the feedback controlled ultrasound system using the cymbal array for noninvasive glucose sensing and insulin delivery. Further studies on the extension of the glucose control will be continued for the effective method of glucose control.

Original languageEnglish (US)
Title of host publication9th International Symposium on Therapeutic Ultrasound - ISTU 2009
Pages157-160
Number of pages4
Volume1215
DOIs
StatePublished - Mar 30 2010
Event9th International Symposium on Therapeutic Ultrasound, ISTU 2009 - Aix-en-Provence, France
Duration: Sep 24 2009Sep 26 2009

Other

Other9th International Symposium on Therapeutic Ultrasound, ISTU 2009
CountryFrance
CityAix-en-Provence
Period9/24/099/26/09

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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  • Cite this

    Park, E. J., Werner, J. R., Jaiswal, D., & Smith, N. B. (2010). Closed-loop controlled noninvasive ultrasonic glucose sensing and insulin delivery. In 9th International Symposium on Therapeutic Ultrasound - ISTU 2009 (Vol. 1215, pp. 157-160) https://doi.org/10.1063/1.3367129