Cluster secondary ion mass spectrometrys

Joseph Kozole, Nicholas Winograd

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In principle, secondary ion mass spectrometry (SIMS) molecule-specific imaging has vast implications in biological research where submicrometer spatial resolution, uppermost surface layer sensitivity, and chemically unmodified sample preparation are essential. Yet SIMS imaging using atomic projectiles has been rather ineffective when applied to biological materials. The common pitfalls experienced during these analyses include low secondary ion yields, extensive fragmentation, restricted mass ranges, and the accumulation of significant physical and chemical damage after sample erosion beyond 1 % of the surface molecules. Collectively, these limitations considerably reduce the amount of material available for detection and result in inadequate sensitivity for most applications. In response, polyatomic (cluster) ions have been introduced as an alternate imaging projectile. Cluster ion bombardment has been observed to enhance secondary ion yields, extend the spectral mass range, and decrease the incidence of physical and chemical damage during sample erosion. The projectiles are expected to considerably increase the number of molecules available for analysis and to significantly improve the overall sensitivity. Hence, the objectives of this chapter are to describe the unique physical basis for the improvements observed during polyatomic bombardment and to identify the emerging biological applications made practical by the introduction of cluster projectiles to SIMS.

Original languageEnglish (US)
Title of host publicationSurface Analysis and Techniques in Biology
PublisherSpringer International Publishing
Pages71-98
Number of pages28
ISBN (Electronic)9783319013602
ISBN (Print)9783319013596
DOIs
StatePublished - Jan 1 2014

Fingerprint

Secondary Ion Mass Spectrometry
Projectiles
Secondary ion mass spectrometry
Ions
Imaging techniques
Molecules
Erosion
Ion bombardment
Biological materials
Incidence
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kozole, J., & Winograd, N. (2014). Cluster secondary ion mass spectrometrys. In Surface Analysis and Techniques in Biology (pp. 71-98). Springer International Publishing. https://doi.org/10.1007/978-3-319-01360-2_4
Kozole, Joseph ; Winograd, Nicholas. / Cluster secondary ion mass spectrometrys. Surface Analysis and Techniques in Biology. Springer International Publishing, 2014. pp. 71-98
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Kozole, J & Winograd, N 2014, Cluster secondary ion mass spectrometrys. in Surface Analysis and Techniques in Biology. Springer International Publishing, pp. 71-98. https://doi.org/10.1007/978-3-319-01360-2_4

Cluster secondary ion mass spectrometrys. / Kozole, Joseph; Winograd, Nicholas.

Surface Analysis and Techniques in Biology. Springer International Publishing, 2014. p. 71-98.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Kozole J, Winograd N. Cluster secondary ion mass spectrometrys. In Surface Analysis and Techniques in Biology. Springer International Publishing. 2014. p. 71-98 https://doi.org/10.1007/978-3-319-01360-2_4