Co-activation patterns in resting-state fMRI signals

Xiao Liu, Nanyin Zhang, Catie Chang, Jeff H. Duyn

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The brain is a complex system that integrates and processes information across multiple time scales by dynamically coordinating activities over brain regions and circuits. Correlations in resting-state functional magnetic resonance imaging (rsfMRI) signals have been widely used to infer functional connectivity of the brain, providing a metric of functional associations that reflects a temporal average over an entire scan (typically several minutes or longer). Not until recently was the study of dynamic brain interactions at much shorter time scales (seconds to minutes) considered for inference of functional connectivity. One method proposed for this objective seeks to identify and extract recurring co-activation patterns (CAPs) that represent instantaneous brain configurations at single time points. Here, we review the development and recent advancement of CAP methodology and other closely related approaches, as well as their applications and associated findings. We also discuss the potential neural origins and behavioral relevance of CAPs, along with methodological issues and future research directions in the analysis of fMRI co-activation patterns.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
JournalNeuroImage
Volume180
DOIs
StatePublished - Oct 15 2018

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Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Liu, Xiao ; Zhang, Nanyin ; Chang, Catie ; Duyn, Jeff H. / Co-activation patterns in resting-state fMRI signals. In: NeuroImage. 2018 ; Vol. 180. pp. 485-494.
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Co-activation patterns in resting-state fMRI signals. / Liu, Xiao; Zhang, Nanyin; Chang, Catie; Duyn, Jeff H.

In: NeuroImage, Vol. 180, 15.10.2018, p. 485-494.

Research output: Contribution to journalReview article

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