Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity

Thomas M. Aune, Joel S. Parker, Kevin Maas, Zheng Liu, Nancy J. Olsen, Jason H. Moore

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Autoimmune diseases arise from complex interactions between environmental and genetic factors. Genetic linkage scans show that different autoimmune diseases share overlapping susceptibility loci. Lymphocytes from individuals with different autoimmune diseases, as well as unaffected first-degree relatives, also share a common gene expression profile. We sought to determine if genes within this autoimmune expression profile were nonrandomly distributed in the genome and if their distribution overlapped with shared disease susceptibility loci. We found that differentially expressed genes were distributed in a nonrandom fashion in chromosomal domains within the genome. Furthermore, positions of these domains were not statistically different from a number of shared autoimmune disease susceptibility loci. To our knowledge, this is the first study showing concordance between gene expression and genetic linkage results in common complex multifactorial human diseases.

Original languageEnglish (US)
Pages (from-to)162-172
Number of pages11
JournalGenetic Epidemiology
Volume27
Issue number2
DOIs
StatePublished - Sep 2004

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Genetics(clinical)

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