The reaction of N-alkylbenzaldimines with carbon monoxide (CO) in the presence of cobalt (Co) catalysts resulted in the formation of N-alkylphthalimidines (Table 1). Their formation is proposed to occur by C-H activation of the aryl ring, migratory insertion of the hydride species into the benzaldimine functionality, CO coordination, and insertion into the Co-C bond, followed by reductive elimination of the N-alkylphthalimidine and regeneration of the starting Co species (Scheme 4). Deuterium (2H)-labeling NMR studies are consistent with this mechanism (Scheme 5).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry