Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

Tamas L. Horvath, Sabrina Diano, Csaba Leranth, Luis Miguel Garcia-Segura, Michael A. Cowley, Marya Shanabrough, John D. Elsworth, Peter Sotonyi, Robert H. Roth, Edwin H. Dietrich, Russel T. Matthews, Colin J. Barnstable, D. Eugene Redmond

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

Original languageEnglish (US)
Pages (from-to)2757-2760
Number of pages4
JournalEndocrinology
Volume144
Issue number7
DOIs
StatePublished - Jul 1 2003

All Science Journal Classification (ASJC) codes

  • Endocrinology

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