Cognitive dysfunction in postural tachycardia syndrome

Amy C. Arnold, Kirsten Haman, Emily M. Garland, Vidya Raj, William D. Dupont, Italo Biaggioni, David Robertson, Satish R. Raj

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mental clouding is an almost universal complaint among patients with postural tachycardia syndrome (POTS) but remains poorly understood. Thus, we have determined whether POTS patients exhibit deficits during neuropsychological testing relative to healthy subjects. A comprehensive battery of validated neuropsychological tests was administered to 28 female POTS patients and 24 healthy subjects in a semi-recumbent position. Healthy subjects were matched to POTS patients on age and gender. Selective attention, a primary outcome measure, and cognitive processing speed were reduced in POTS patients compared with healthy subjects (Ruff 2&7 Speed t-score: 40± 9 compared with 49± 8; P=0.009; Symbol Digit Modalities Test t-score: 45± 12 compared with 51± 8; P=0.011). Measures of executive function were also lower in POTS patients (Trails B t-score: 46± 8 compared with 52± 8; P=0.007; Stroop Word Color t-score: 45± 10 compared with 56± 8; P=0.001), suggesting difficulties in tracking and mental flexibility. Measures of sustained attention, psychomotor speed, memory function or verbal fluency were not significantly different between groups. The present study provides evidence for deficits in selective attention and cognitive processing in patients with POTS, in the seated position when orthostatic stress is minimized. In contrast, other measures of cognitive function, including memory assessments, were not impaired in these patients, suggesting selectivity in these deficits. These findings provide new insight into the profile of cognitive dysfunction in POTS and provide the basis for further studies to identify clinical strategies to better manage the mental clouding associated with this condition.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalClinical Science
Volume128
Issue number1
DOIs
StatePublished - Jan 1 2015

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Postural Orthostatic Tachycardia Syndrome
Healthy Volunteers
Cognitive Dysfunction
Neuropsychological Tests
Executive Function
Posture
Cognition
Color
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Arnold, A. C., Haman, K., Garland, E. M., Raj, V., Dupont, W. D., Biaggioni, I., ... Raj, S. R. (2015). Cognitive dysfunction in postural tachycardia syndrome. Clinical Science, 128(1), 39-45. https://doi.org/10.1042/CS20140251
Arnold, Amy C. ; Haman, Kirsten ; Garland, Emily M. ; Raj, Vidya ; Dupont, William D. ; Biaggioni, Italo ; Robertson, David ; Raj, Satish R. / Cognitive dysfunction in postural tachycardia syndrome. In: Clinical Science. 2015 ; Vol. 128, No. 1. pp. 39-45.
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Arnold, AC, Haman, K, Garland, EM, Raj, V, Dupont, WD, Biaggioni, I, Robertson, D & Raj, SR 2015, 'Cognitive dysfunction in postural tachycardia syndrome', Clinical Science, vol. 128, no. 1, pp. 39-45. https://doi.org/10.1042/CS20140251

Cognitive dysfunction in postural tachycardia syndrome. / Arnold, Amy C.; Haman, Kirsten; Garland, Emily M.; Raj, Vidya; Dupont, William D.; Biaggioni, Italo; Robertson, David; Raj, Satish R.

In: Clinical Science, Vol. 128, No. 1, 01.01.2015, p. 39-45.

Research output: Contribution to journalArticle

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Arnold AC, Haman K, Garland EM, Raj V, Dupont WD, Biaggioni I et al. Cognitive dysfunction in postural tachycardia syndrome. Clinical Science. 2015 Jan 1;128(1):39-45. https://doi.org/10.1042/CS20140251