Coincidence detection or temporal integration? What the neurons in somatosensory cortex are doing

Stephane A. Roy, Kevin D. Alloway

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

To assess the impact of thalamic synchronization on cortical responsiveness, we used conditional cross-correlation analysis to measure the probability of neuronal discharges in somatosensory cortex as a function of the time between discharges in pairs of simultaneously recorded neurons in the ventrobasal thalamus. Among 26 neuronal trios, we found that thalamocortical efficacy after synchronous thalamic activity was nearly twice as large as the efficacy rate obtained when pairs of thalamic neurons discharged asynchronously. Nearly half of these neuronal trios displayed cooperative effects in which the cortical discharge probability after synchronous thalamic events was larger than could be predicted from the efficacy rate of individual thalamic discharges. In these cases of heterosynaptic cooperativity, thalamocortical efficacy declined to asymptotic levels when the interspike intervals were >6-8 msec. These results indicate that thalamic synchronization has a significant impact on cortical responsiveness and suggest that neuronal synchronization may play a critical role in the transmission of sensory information from one brain region to another.

Original languageEnglish (US)
Pages (from-to)2462-2473
Number of pages12
JournalJournal of Neuroscience
Volume21
Issue number7
StatePublished - Apr 1 2001

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this