Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm: Translation from animal models to human control

Jennifer L. Collinger, Michael A. Kryger, Richard Barbara, Timothy Betler, Kristen Bowsher, Elke H.P. Brown, Samuel T. Clanton, Alan D. Degenhart, Stephen T. Foldes, Robert A. Gaunt, Ferenc E. Gyulai, Elizabeth A. Harchick, Deborah Harrington, John B. Helder, Timothy Hemmes, Matthew S. Johannes, Kapil D. Katyal, Geoffrey S.F. Ling, Angus J.C. Mcmorland, Karina PalkoMatthew P. Para, Janet Scheuermann, Andrew B. Schwartz, Elizabeth R. Skidmore, Florian Solzbacher, Anita V. Srikameswaran, Dennis P. Swanson, Scott Swetz, Elizabeth C. Tyler-Kabara, Meel Velliste, Wei Wang, Douglas J. Weber, Brian Wodlinger, Michael L. Boninger

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Our research group recently demonstrated that a person with tetraplegia could use a brain-computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short-term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real-world clinical situations. This article is a U.S. Government work and is in the public domain in the USA.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalClinical and Translational Science
Volume7
Issue number1
DOIs
StatePublished - Feb 1 2014

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Brain-Computer Interfaces
Brain computer interface
Animals
Animal Models
Robotics
Research
Research Personnel
Physical and Rehabilitation Medicine
Anesthesiology
Occupational therapy
Quadriplegia
Public Sector
Occupational Therapy
Neurosurgery
Robotic arms
Epilepsy
Teaching
Software
Clinical Trials
Psychology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Collinger, Jennifer L. ; Kryger, Michael A. ; Barbara, Richard ; Betler, Timothy ; Bowsher, Kristen ; Brown, Elke H.P. ; Clanton, Samuel T. ; Degenhart, Alan D. ; Foldes, Stephen T. ; Gaunt, Robert A. ; Gyulai, Ferenc E. ; Harchick, Elizabeth A. ; Harrington, Deborah ; Helder, John B. ; Hemmes, Timothy ; Johannes, Matthew S. ; Katyal, Kapil D. ; Ling, Geoffrey S.F. ; Mcmorland, Angus J.C. ; Palko, Karina ; Para, Matthew P. ; Scheuermann, Janet ; Schwartz, Andrew B. ; Skidmore, Elizabeth R. ; Solzbacher, Florian ; Srikameswaran, Anita V. ; Swanson, Dennis P. ; Swetz, Scott ; Tyler-Kabara, Elizabeth C. ; Velliste, Meel ; Wang, Wei ; Weber, Douglas J. ; Wodlinger, Brian ; Boninger, Michael L. / Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm : Translation from animal models to human control. In: Clinical and Translational Science. 2014 ; Vol. 7, No. 1. pp. 52-59.
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Collinger, JL, Kryger, MA, Barbara, R, Betler, T, Bowsher, K, Brown, EHP, Clanton, ST, Degenhart, AD, Foldes, ST, Gaunt, RA, Gyulai, FE, Harchick, EA, Harrington, D, Helder, JB, Hemmes, T, Johannes, MS, Katyal, KD, Ling, GSF, Mcmorland, AJC, Palko, K, Para, MP, Scheuermann, J, Schwartz, AB, Skidmore, ER, Solzbacher, F, Srikameswaran, AV, Swanson, DP, Swetz, S, Tyler-Kabara, EC, Velliste, M, Wang, W, Weber, DJ, Wodlinger, B & Boninger, ML 2014, 'Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm: Translation from animal models to human control', Clinical and Translational Science, vol. 7, no. 1, pp. 52-59. https://doi.org/10.1111/cts.12086

Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm : Translation from animal models to human control. / Collinger, Jennifer L.; Kryger, Michael A.; Barbara, Richard; Betler, Timothy; Bowsher, Kristen; Brown, Elke H.P.; Clanton, Samuel T.; Degenhart, Alan D.; Foldes, Stephen T.; Gaunt, Robert A.; Gyulai, Ferenc E.; Harchick, Elizabeth A.; Harrington, Deborah; Helder, John B.; Hemmes, Timothy; Johannes, Matthew S.; Katyal, Kapil D.; Ling, Geoffrey S.F.; Mcmorland, Angus J.C.; Palko, Karina; Para, Matthew P.; Scheuermann, Janet; Schwartz, Andrew B.; Skidmore, Elizabeth R.; Solzbacher, Florian; Srikameswaran, Anita V.; Swanson, Dennis P.; Swetz, Scott; Tyler-Kabara, Elizabeth C.; Velliste, Meel; Wang, Wei; Weber, Douglas J.; Wodlinger, Brian; Boninger, Michael L.

In: Clinical and Translational Science, Vol. 7, No. 1, 01.02.2014, p. 52-59.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm

T2 - Translation from animal models to human control

AU - Collinger, Jennifer L.

AU - Kryger, Michael A.

AU - Barbara, Richard

AU - Betler, Timothy

AU - Bowsher, Kristen

AU - Brown, Elke H.P.

AU - Clanton, Samuel T.

AU - Degenhart, Alan D.

AU - Foldes, Stephen T.

AU - Gaunt, Robert A.

AU - Gyulai, Ferenc E.

AU - Harchick, Elizabeth A.

AU - Harrington, Deborah

AU - Helder, John B.

AU - Hemmes, Timothy

AU - Johannes, Matthew S.

AU - Katyal, Kapil D.

AU - Ling, Geoffrey S.F.

AU - Mcmorland, Angus J.C.

AU - Palko, Karina

AU - Para, Matthew P.

AU - Scheuermann, Janet

AU - Schwartz, Andrew B.

AU - Skidmore, Elizabeth R.

AU - Solzbacher, Florian

AU - Srikameswaran, Anita V.

AU - Swanson, Dennis P.

AU - Swetz, Scott

AU - Tyler-Kabara, Elizabeth C.

AU - Velliste, Meel

AU - Wang, Wei

AU - Weber, Douglas J.

AU - Wodlinger, Brian

AU - Boninger, Michael L.

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Our research group recently demonstrated that a person with tetraplegia could use a brain-computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short-term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real-world clinical situations. This article is a U.S. Government work and is in the public domain in the USA.

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