Collection and use of exposure data from human milk biomonitoring in the United States

Suzanne E. Fenton, Marian Condon, Adrienne S. Ettinger, Judy S. LaKind, Ann Mason, Melissa McDiarmid, Zhengmin Qian, Sherry G. Selevan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Human milk is a unique biological matrix that can be used to estimate exposures in both the mother and the breastfed infant. In addition, the presence of environmental chemicals in human milk may act as a sentinel for exposures to a broader population. Several factors play a role in determining the quantity of chemicals transferred to milk and, subsequently, to the breastfeeding infant, including maternal, infant, and chemical characteristics. Exposure to certain environmental chemicals during critical periods can disrupt normal infant development, yet few data exist to quantify the hazards posed by environmental chemicals in human milk. Chemicals measured in human milk may also provide, insights to agents suspect in altering breast development and breast-related disease risk. Carefully designed exposure assessment and toxicokinetic studies are needed to elucidate mechanisms and establish relationships between human milk and other biologic matrices. Data from human milk biomonitoring studies can be used to inform and validate models that integrate information about chemical properties, human metabolism, and biomarker concentrations. Additional research is needed to determine the degree to which environmental chemicals enter, are present in, and are excreted from human milk, their impact on the host (mother), and the extent of their bioavailability to breastfeeding infants. This article describes how the collection and use of exposure data from human milk biomonitoring in the United States can be designed to inform future research and policy. Copyright

Original languageEnglish (US)
Pages (from-to)1691-1712
Number of pages22
JournalJournal of Toxicology and Environmental Health - Part A
Volume68
Issue number20
DOIs
StatePublished - Oct 22 2005

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Environmental Monitoring
Human Milk
Breast Feeding
Surrogate Mothers
Mothers
Breast Diseases
Biomarkers
Child Development
Metabolism
Chemical properties
Biological Availability
Hazards
Milk
Breast
Research
Population

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Fenton, S. E., Condon, M., Ettinger, A. S., LaKind, J. S., Mason, A., McDiarmid, M., ... Selevan, S. G. (2005). Collection and use of exposure data from human milk biomonitoring in the United States. Journal of Toxicology and Environmental Health - Part A, 68(20), 1691-1712. https://doi.org/10.1080/15287390500225708
Fenton, Suzanne E. ; Condon, Marian ; Ettinger, Adrienne S. ; LaKind, Judy S. ; Mason, Ann ; McDiarmid, Melissa ; Qian, Zhengmin ; Selevan, Sherry G. / Collection and use of exposure data from human milk biomonitoring in the United States. In: Journal of Toxicology and Environmental Health - Part A. 2005 ; Vol. 68, No. 20. pp. 1691-1712.
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Fenton, SE, Condon, M, Ettinger, AS, LaKind, JS, Mason, A, McDiarmid, M, Qian, Z & Selevan, SG 2005, 'Collection and use of exposure data from human milk biomonitoring in the United States', Journal of Toxicology and Environmental Health - Part A, vol. 68, no. 20, pp. 1691-1712. https://doi.org/10.1080/15287390500225708

Collection and use of exposure data from human milk biomonitoring in the United States. / Fenton, Suzanne E.; Condon, Marian; Ettinger, Adrienne S.; LaKind, Judy S.; Mason, Ann; McDiarmid, Melissa; Qian, Zhengmin; Selevan, Sherry G.

In: Journal of Toxicology and Environmental Health - Part A, Vol. 68, No. 20, 22.10.2005, p. 1691-1712.

Research output: Contribution to journalArticle

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