Combination Emtricitabine and Tenofovir Disoproxil Fumarate Prevents Vaginal Simian/Human Immunodeficiency Virus Infection in Macaques Harboring Chlamydia trachomatis and Trichomonas vaginalis

Jessica Radzio, Tara Henning, Leecresia Jenkins, Shanon Ellis, Carol Farshy, Christi Phillips, Angela Holder, Susan Kuklenyik, Chuong Dinh, Debra Hanson, Janet McNicholl, Walid Heneine, John Papp, Ellen N. Kersh, J. Gerardo García-Lerma

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7 Scopus citations

Abstract

Genital inflammation associated with sexually transmitted infections increases susceptibility to human immunodeficiency virus (HIV), but it is unclear whether the increased risk can reduce the efficacy of pre-exposure prophylaxis (PrEP). We investigated whether coinfection of macaques with Chlamydia trachomatis and Trichomonas vaginalis decreases the prophylactic efficacy of oral emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF). Macaques were exposed to simian/human immunodeficiency virus (SHIV) vaginally each week for up to 16 weeks and received placebo or FTC/TDF pericoitally. All animals in the placebo group were infected with SHIV, while 4 of 6 PrEP recipients remained uninfected (P =. 03). Oral FTC/TDF maintains efficacy in a macaque model of sexually transmitted coinfection, although the infection of 2 macaques signals a modest loss of PrEP activity.

Original languageEnglish (US)
Pages (from-to)1541-1545
Number of pages5
JournalJournal of Infectious Diseases
Volume213
Issue number10
DOIs
StatePublished - May 15 2016

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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    Radzio, J., Henning, T., Jenkins, L., Ellis, S., Farshy, C., Phillips, C., Holder, A., Kuklenyik, S., Dinh, C., Hanson, D., McNicholl, J., Heneine, W., Papp, J., Kersh, E. N., & García-Lerma, J. G. (2016). Combination Emtricitabine and Tenofovir Disoproxil Fumarate Prevents Vaginal Simian/Human Immunodeficiency Virus Infection in Macaques Harboring Chlamydia trachomatis and Trichomonas vaginalis. Journal of Infectious Diseases, 213(10), 1541-1545. https://doi.org/10.1093/infdis/jiw002