Combined medication and cognitive therapy for generalized anxiety disorder

Paul Crits-Christoph, Michelle G. Newman, Karl Rickels, Robert Gallop, Mary Beth Connolly Gibbons, Jessica L. Hamilton, Sarah Ring-Kurtz, Amy M. Pastva

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The current study assessed efficacy of combined cognitive behavioral therapy (CBT) and venlafaxine XR compared to venlafaxine XR alone in the treatment of generalized anxiety disorder (GAD) within settings where medication is typically offered as the treatment for this disorder. Patients with DSM-IV-diagnosed GAD who were recently enrolled in a long-term venlafaxine XR study were randomly offered (n= 77), or not offered (n= 40), the option of adding 12 sessions of CBT. Of those offered CBT, 33% (n= 26) accepted and attended at least one treatment session. There were no differences between the combined treatment group and the medication only group on primary or secondary efficacy measures in any of the sample comparisons. Many patients who present in medical/psychopharmacology settings seeking treatment for GAD decline the opportunity to receive adjunctive treatment. Of those that receive CBT, there appears to be no additional benefit of combined treatment compared to venlafaxine XR alone.

Original languageEnglish (US)
Pages (from-to)1087-1094
Number of pages8
JournalJournal of Anxiety Disorders
Issue number8
StatePublished - Dec 2011

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health


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