Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders

Ashley Acheson, S. Andrea Wijtenburg, Laura M. Rowland, Bethany Cara Bray, Frank Gaston, Charles W. Mathias, Peter T. Fox, William R. Lovallo, Susan N. Wright, L. Elliot Hong, Stephen Mcguire, Peter Kochunov, Donald M. Dougherty

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Individuals with a family history of substance use disorder (FH+) show impaired frontal white matter as indicated by diffusion tensor imaging (DTI). This impairment may be due to impaired or delayed development of myelin in frontal regions, potentially contributing to this population's increased risk for developing substance use disorders. In this study, we examined high angular resolution DTI and proton magnetic resonance spectroscopy data from the anterior corona radiata were collected in 80 FH+ and 34 FH- youths (12.9±1.0 years old). White matter integrity indices included fractional anisotropy (FA), N-acetylaspartate (NAA), and total choline (tCho). Lower FA suggests decreased myelination. Decreased NAA coupled with higher tCho suggests impaired build-up and maintenance of cerebral myelin and consequently greater breakdown of cellular membranes. We found FH+ youths had lower FA (P<0.0001) and NAA (P=0.017) and higher tCho (P=0.04). FH density (number of parents and grandparents with substance use disorders) was negatively correlated with FA (P<0.0001) and NAA (P=0.011) and positively correlated with tCho (P=0.001). FA was independently predicted by both FH density (P =0.006) and NAA (P= 0.002), and NAA and tCho were both independent predictors of FH density (P<0.001). Our finding of lower frontal FA in FH+ youths corresponding to lower NAA and increased tCho is consistent with delayed or impaired development of frontal white matter in FH+ youths. Longitudinal studies are needed to determine how these differences relate to substance use outcomes.

Original languageEnglish (US)
Pages (from-to)5877-5887
Number of pages11
JournalHuman Brain Mapping
Volume35
Issue number12
DOIs
StatePublished - Dec 1 2014

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Diffusion Tensor Imaging
Anisotropy
Substance-Related Disorders
Magnetic Resonance Spectroscopy
Choline
Myelin Sheath
N-acetylaspartate
White Matter
Longitudinal Studies
Parents
Maintenance
Membranes
Population

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Acheson, Ashley ; Wijtenburg, S. Andrea ; Rowland, Laura M. ; Bray, Bethany Cara ; Gaston, Frank ; Mathias, Charles W. ; Fox, Peter T. ; Lovallo, William R. ; Wright, Susan N. ; Hong, L. Elliot ; Mcguire, Stephen ; Kochunov, Peter ; Dougherty, Donald M. / Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders. In: Human Brain Mapping. 2014 ; Vol. 35, No. 12. pp. 5877-5887.
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abstract = "Individuals with a family history of substance use disorder (FH+) show impaired frontal white matter as indicated by diffusion tensor imaging (DTI). This impairment may be due to impaired or delayed development of myelin in frontal regions, potentially contributing to this population's increased risk for developing substance use disorders. In this study, we examined high angular resolution DTI and proton magnetic resonance spectroscopy data from the anterior corona radiata were collected in 80 FH+ and 34 FH- youths (12.9±1.0 years old). White matter integrity indices included fractional anisotropy (FA), N-acetylaspartate (NAA), and total choline (tCho). Lower FA suggests decreased myelination. Decreased NAA coupled with higher tCho suggests impaired build-up and maintenance of cerebral myelin and consequently greater breakdown of cellular membranes. We found FH+ youths had lower FA (P<0.0001) and NAA (P=0.017) and higher tCho (P=0.04). FH density (number of parents and grandparents with substance use disorders) was negatively correlated with FA (P<0.0001) and NAA (P=0.011) and positively correlated with tCho (P=0.001). FA was independently predicted by both FH density (P =0.006) and NAA (P= 0.002), and NAA and tCho were both independent predictors of FH density (P<0.001). Our finding of lower frontal FA in FH+ youths corresponding to lower NAA and increased tCho is consistent with delayed or impaired development of frontal white matter in FH+ youths. Longitudinal studies are needed to determine how these differences relate to substance use outcomes.",
author = "Ashley Acheson and Wijtenburg, {S. Andrea} and Rowland, {Laura M.} and Bray, {Bethany Cara} and Frank Gaston and Mathias, {Charles W.} and Fox, {Peter T.} and Lovallo, {William R.} and Wright, {Susan N.} and Hong, {L. Elliot} and Stephen Mcguire and Peter Kochunov and Dougherty, {Donald M.}",
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Acheson, A, Wijtenburg, SA, Rowland, LM, Bray, BC, Gaston, F, Mathias, CW, Fox, PT, Lovallo, WR, Wright, SN, Hong, LE, Mcguire, S, Kochunov, P & Dougherty, DM 2014, 'Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders', Human Brain Mapping, vol. 35, no. 12, pp. 5877-5887. https://doi.org/10.1002/hbm.22591

Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders. / Acheson, Ashley; Wijtenburg, S. Andrea; Rowland, Laura M.; Bray, Bethany Cara; Gaston, Frank; Mathias, Charles W.; Fox, Peter T.; Lovallo, William R.; Wright, Susan N.; Hong, L. Elliot; Mcguire, Stephen; Kochunov, Peter; Dougherty, Donald M.

In: Human Brain Mapping, Vol. 35, No. 12, 01.12.2014, p. 5877-5887.

Research output: Contribution to journalArticle

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T1 - Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders

AU - Acheson, Ashley

AU - Wijtenburg, S. Andrea

AU - Rowland, Laura M.

AU - Bray, Bethany Cara

AU - Gaston, Frank

AU - Mathias, Charles W.

AU - Fox, Peter T.

AU - Lovallo, William R.

AU - Wright, Susan N.

AU - Hong, L. Elliot

AU - Mcguire, Stephen

AU - Kochunov, Peter

AU - Dougherty, Donald M.

PY - 2014/12/1

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N2 - Individuals with a family history of substance use disorder (FH+) show impaired frontal white matter as indicated by diffusion tensor imaging (DTI). This impairment may be due to impaired or delayed development of myelin in frontal regions, potentially contributing to this population's increased risk for developing substance use disorders. In this study, we examined high angular resolution DTI and proton magnetic resonance spectroscopy data from the anterior corona radiata were collected in 80 FH+ and 34 FH- youths (12.9±1.0 years old). White matter integrity indices included fractional anisotropy (FA), N-acetylaspartate (NAA), and total choline (tCho). Lower FA suggests decreased myelination. Decreased NAA coupled with higher tCho suggests impaired build-up and maintenance of cerebral myelin and consequently greater breakdown of cellular membranes. We found FH+ youths had lower FA (P<0.0001) and NAA (P=0.017) and higher tCho (P=0.04). FH density (number of parents and grandparents with substance use disorders) was negatively correlated with FA (P<0.0001) and NAA (P=0.011) and positively correlated with tCho (P=0.001). FA was independently predicted by both FH density (P =0.006) and NAA (P= 0.002), and NAA and tCho were both independent predictors of FH density (P<0.001). Our finding of lower frontal FA in FH+ youths corresponding to lower NAA and increased tCho is consistent with delayed or impaired development of frontal white matter in FH+ youths. Longitudinal studies are needed to determine how these differences relate to substance use outcomes.

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