Combining short-term interval training with caloric restriction improves ß-cell function in obese adults

Monique E. Francois, Nicole Gilbertson, Natalie Z.M. Eichner, Emily M. Heiston, Chiara Fabris, Marc Breton, J. Hunter Mehaffey, Taryn Hassinger, Peter T. Hallowell, Steven K. Malin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on ß-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 ± 6 kg/m2) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and ß-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IRfasting) insulin resistance (IR). LCD + INT, but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR by 16% (p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved skeletal muscle DI was associated with lower glucose tAUC (r = −0.57, p < 0.01). Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and these findings relate to ß-cell function. These data support LCD + INT for preserving pancreatic function for type 2 diabetes prevention.

Original languageEnglish (US)
Article number717
JournalNutrients
Volume10
Issue number6
DOIs
StatePublished - Jun 3 2018

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Caloric Restriction
low calorie diet
exercise
insulin secretion
Glucose
Exercise
insulin resistance
cells
skeletal muscle
Insulin Resistance
Skeletal Muscle
glucose
Insulin
Area Under Curve
glucose tolerance
liver
Liver
Glucose Tolerance Test
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Francois, M. E., Gilbertson, N., Eichner, N. Z. M., Heiston, E. M., Fabris, C., Breton, M., ... Malin, S. K. (2018). Combining short-term interval training with caloric restriction improves ß-cell function in obese adults. Nutrients, 10(6), [717]. https://doi.org/10.3390/nu10060717
Francois, Monique E. ; Gilbertson, Nicole ; Eichner, Natalie Z.M. ; Heiston, Emily M. ; Fabris, Chiara ; Breton, Marc ; Mehaffey, J. Hunter ; Hassinger, Taryn ; Hallowell, Peter T. ; Malin, Steven K. / Combining short-term interval training with caloric restriction improves ß-cell function in obese adults. In: Nutrients. 2018 ; Vol. 10, No. 6.
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Francois, ME, Gilbertson, N, Eichner, NZM, Heiston, EM, Fabris, C, Breton, M, Mehaffey, JH, Hassinger, T, Hallowell, PT & Malin, SK 2018, 'Combining short-term interval training with caloric restriction improves ß-cell function in obese adults', Nutrients, vol. 10, no. 6, 717. https://doi.org/10.3390/nu10060717

Combining short-term interval training with caloric restriction improves ß-cell function in obese adults. / Francois, Monique E.; Gilbertson, Nicole; Eichner, Natalie Z.M.; Heiston, Emily M.; Fabris, Chiara; Breton, Marc; Mehaffey, J. Hunter; Hassinger, Taryn; Hallowell, Peter T.; Malin, Steven K.

In: Nutrients, Vol. 10, No. 6, 717, 03.06.2018.

Research output: Contribution to journalArticle

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AU - Francois, Monique E.

AU - Gilbertson, Nicole

AU - Eichner, Natalie Z.M.

AU - Heiston, Emily M.

AU - Fabris, Chiara

AU - Breton, Marc

AU - Mehaffey, J. Hunter

AU - Hassinger, Taryn

AU - Hallowell, Peter T.

AU - Malin, Steven K.

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N2 - Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on ß-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 ± 6 kg/m2) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and ß-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IRfasting) insulin resistance (IR). LCD + INT, but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR by 16% (p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved skeletal muscle DI was associated with lower glucose tAUC (r = −0.57, p < 0.01). Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and these findings relate to ß-cell function. These data support LCD + INT for preserving pancreatic function for type 2 diabetes prevention.

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