Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy

Kathleen M. Sturgeon, Lorraine T. Dean, Mariane Heroux, Jessica Kane, Toni Bauer, Erica Palmer, Jin Long, Shannon Lynch, Linda Jacobs, David B. Sarwer, Mary B. Leonard, Kathryn Schmitz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause. Methods: A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed. Results: Average adherence to all program components was 74.8 %. Women in the intervention group maintained their cardiovascular fitness level over the 12 months (1.1 ± 7.9 %), while the control group significantly decreased fitness capacity (−4.0 ± 7.5 %). There was a significant difference between groups in percent change of whole body bone area (−0.8 ± 2.5 control and 0.5 ± 1.30 intervention). We also observed decreased BMI (−4.7 ± 6.2 %) and fat mass (−8.6 ± 12.7 %) in the intervention group due to significant concomitant decreases in caloric intake and increases in caloric expenditure. The control group demonstrated decreased caloric intake and decreased lean tissue mass. Conclusions: In this population at high risk for detrimental cardiovascular and bone outcomes, a commercially available lifestyle intervention program mitigated a decline in cardiovascular health, improved bone health, and decreased weight through fat loss. Implications for cancer survivors: Precision Nutrition Coaching has shown benefit in breast cancer survivors for reduced risk of deleterious cardiovascular and bone outcomes.

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalJournal of Cancer Survivorship
Volume11
Issue number2
DOIs
StatePublished - Apr 1 2017

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Ovariectomy
Survivors
Life Style
Randomized Controlled Trials
Breast Neoplasms
Bone and Bones
Health
Energy Intake
Premature Menopause
Fats
Control Groups
compound A 12
Leisure Activities
Muscle Strength
Health Expenditures
Body Composition
Bone Density
Safety
Weights and Measures
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Oncology(nursing)

Cite this

Sturgeon, Kathleen M. ; Dean, Lorraine T. ; Heroux, Mariane ; Kane, Jessica ; Bauer, Toni ; Palmer, Erica ; Long, Jin ; Lynch, Shannon ; Jacobs, Linda ; Sarwer, David B. ; Leonard, Mary B. ; Schmitz, Kathryn. / Commercially available lifestyle modification program : randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy. In: Journal of Cancer Survivorship. 2017 ; Vol. 11, No. 2. pp. 246-255.
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abstract = "Purpose: The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause. Methods: A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed. Results: Average adherence to all program components was 74.8 {\%}. Women in the intervention group maintained their cardiovascular fitness level over the 12 months (1.1 ± 7.9 {\%}), while the control group significantly decreased fitness capacity (−4.0 ± 7.5 {\%}). There was a significant difference between groups in percent change of whole body bone area (−0.8 ± 2.5 control and 0.5 ± 1.30 intervention). We also observed decreased BMI (−4.7 ± 6.2 {\%}) and fat mass (−8.6 ± 12.7 {\%}) in the intervention group due to significant concomitant decreases in caloric intake and increases in caloric expenditure. The control group demonstrated decreased caloric intake and decreased lean tissue mass. Conclusions: In this population at high risk for detrimental cardiovascular and bone outcomes, a commercially available lifestyle intervention program mitigated a decline in cardiovascular health, improved bone health, and decreased weight through fat loss. Implications for cancer survivors: Precision Nutrition Coaching has shown benefit in breast cancer survivors for reduced risk of deleterious cardiovascular and bone outcomes.",
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Commercially available lifestyle modification program : randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy. / Sturgeon, Kathleen M.; Dean, Lorraine T.; Heroux, Mariane; Kane, Jessica; Bauer, Toni; Palmer, Erica; Long, Jin; Lynch, Shannon; Jacobs, Linda; Sarwer, David B.; Leonard, Mary B.; Schmitz, Kathryn.

In: Journal of Cancer Survivorship, Vol. 11, No. 2, 01.04.2017, p. 246-255.

Research output: Contribution to journalArticle

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T2 - randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy

AU - Sturgeon, Kathleen M.

AU - Dean, Lorraine T.

AU - Heroux, Mariane

AU - Kane, Jessica

AU - Bauer, Toni

AU - Palmer, Erica

AU - Long, Jin

AU - Lynch, Shannon

AU - Jacobs, Linda

AU - Sarwer, David B.

AU - Leonard, Mary B.

AU - Schmitz, Kathryn

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N2 - Purpose: The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause. Methods: A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed. Results: Average adherence to all program components was 74.8 %. Women in the intervention group maintained their cardiovascular fitness level over the 12 months (1.1 ± 7.9 %), while the control group significantly decreased fitness capacity (−4.0 ± 7.5 %). There was a significant difference between groups in percent change of whole body bone area (−0.8 ± 2.5 control and 0.5 ± 1.30 intervention). We also observed decreased BMI (−4.7 ± 6.2 %) and fat mass (−8.6 ± 12.7 %) in the intervention group due to significant concomitant decreases in caloric intake and increases in caloric expenditure. The control group demonstrated decreased caloric intake and decreased lean tissue mass. Conclusions: In this population at high risk for detrimental cardiovascular and bone outcomes, a commercially available lifestyle intervention program mitigated a decline in cardiovascular health, improved bone health, and decreased weight through fat loss. Implications for cancer survivors: Precision Nutrition Coaching has shown benefit in breast cancer survivors for reduced risk of deleterious cardiovascular and bone outcomes.

AB - Purpose: The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause. Methods: A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed. Results: Average adherence to all program components was 74.8 %. Women in the intervention group maintained their cardiovascular fitness level over the 12 months (1.1 ± 7.9 %), while the control group significantly decreased fitness capacity (−4.0 ± 7.5 %). There was a significant difference between groups in percent change of whole body bone area (−0.8 ± 2.5 control and 0.5 ± 1.30 intervention). We also observed decreased BMI (−4.7 ± 6.2 %) and fat mass (−8.6 ± 12.7 %) in the intervention group due to significant concomitant decreases in caloric intake and increases in caloric expenditure. The control group demonstrated decreased caloric intake and decreased lean tissue mass. Conclusions: In this population at high risk for detrimental cardiovascular and bone outcomes, a commercially available lifestyle intervention program mitigated a decline in cardiovascular health, improved bone health, and decreased weight through fat loss. Implications for cancer survivors: Precision Nutrition Coaching has shown benefit in breast cancer survivors for reduced risk of deleterious cardiovascular and bone outcomes.

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