Commissural size in neonatal rats

Effects of sex and prenatal alcohol exposure

Betty Zimmerberg, Lisabeth Scalzi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Sex differences have been reported in the size of the adult corpus callosum in both humans and rodents. This experiment investigated whether sex and/or different prenatal treatment conditions would influence commissural size at birth. Male and female 3-day-old Long Evans rats were selected from one of three prenatal treatment histories: prenatal alcohol-exposed (35% ethanol-derived calories, 35% EDC), nutritional control (0% ethanol-derived calories, 0% EDC) or standard control (lab chow). Midline sagittal areas of the corpus callosum and the anterior commissure were determined for these subjects. Male control subjects had significantly larger callosal areas than females. Prenatal alcohol exposure significantly abolished this sexual dimorphism, with 35% EDC males having a significantly smaller callosal area than males from both control groups. This effect was independent of prenatal treatment differences in body or brain size. There were no significant sex differences in the midline sagittal area of the anterior commissure, nor were there any apparent effects of prenatal treatment on this measure. These results indicate that sex differences in the size of the corpus callosum are present at birth. Since a difference in myelination cannot account for this difference in area, there may be a sex difference in the number of fibers or in the average fiber size. Additionally, the effects of prenatal alcohol exposure on male, but not female, offspring suggest that this alcohol-related birth defect is hormonally mediated.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalInternational Journal of Developmental Neuroscience
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1989

Fingerprint

Corpus Callosum
Sex Characteristics
Alcohols
Ethanol
Parturition
Fetal Alcohol Spectrum Disorders
Long Evans Rats
Rodentia
Control Groups
Brain

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Cite this

@article{04355749c08349718d7c308a817b9250,
title = "Commissural size in neonatal rats: Effects of sex and prenatal alcohol exposure",
abstract = "Sex differences have been reported in the size of the adult corpus callosum in both humans and rodents. This experiment investigated whether sex and/or different prenatal treatment conditions would influence commissural size at birth. Male and female 3-day-old Long Evans rats were selected from one of three prenatal treatment histories: prenatal alcohol-exposed (35{\%} ethanol-derived calories, 35{\%} EDC), nutritional control (0{\%} ethanol-derived calories, 0{\%} EDC) or standard control (lab chow). Midline sagittal areas of the corpus callosum and the anterior commissure were determined for these subjects. Male control subjects had significantly larger callosal areas than females. Prenatal alcohol exposure significantly abolished this sexual dimorphism, with 35{\%} EDC males having a significantly smaller callosal area than males from both control groups. This effect was independent of prenatal treatment differences in body or brain size. There were no significant sex differences in the midline sagittal area of the anterior commissure, nor were there any apparent effects of prenatal treatment on this measure. These results indicate that sex differences in the size of the corpus callosum are present at birth. Since a difference in myelination cannot account for this difference in area, there may be a sex difference in the number of fibers or in the average fiber size. Additionally, the effects of prenatal alcohol exposure on male, but not female, offspring suggest that this alcohol-related birth defect is hormonally mediated.",
author = "Betty Zimmerberg and Lisabeth Scalzi",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0736-5748(89)90046-4",
language = "English (US)",
volume = "7",
pages = "81--86",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Elsevier Limited",
number = "1",

}

Commissural size in neonatal rats : Effects of sex and prenatal alcohol exposure. / Zimmerberg, Betty; Scalzi, Lisabeth.

In: International Journal of Developmental Neuroscience, Vol. 7, No. 1, 01.01.1989, p. 81-86.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Commissural size in neonatal rats

T2 - Effects of sex and prenatal alcohol exposure

AU - Zimmerberg, Betty

AU - Scalzi, Lisabeth

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Sex differences have been reported in the size of the adult corpus callosum in both humans and rodents. This experiment investigated whether sex and/or different prenatal treatment conditions would influence commissural size at birth. Male and female 3-day-old Long Evans rats were selected from one of three prenatal treatment histories: prenatal alcohol-exposed (35% ethanol-derived calories, 35% EDC), nutritional control (0% ethanol-derived calories, 0% EDC) or standard control (lab chow). Midline sagittal areas of the corpus callosum and the anterior commissure were determined for these subjects. Male control subjects had significantly larger callosal areas than females. Prenatal alcohol exposure significantly abolished this sexual dimorphism, with 35% EDC males having a significantly smaller callosal area than males from both control groups. This effect was independent of prenatal treatment differences in body or brain size. There were no significant sex differences in the midline sagittal area of the anterior commissure, nor were there any apparent effects of prenatal treatment on this measure. These results indicate that sex differences in the size of the corpus callosum are present at birth. Since a difference in myelination cannot account for this difference in area, there may be a sex difference in the number of fibers or in the average fiber size. Additionally, the effects of prenatal alcohol exposure on male, but not female, offspring suggest that this alcohol-related birth defect is hormonally mediated.

AB - Sex differences have been reported in the size of the adult corpus callosum in both humans and rodents. This experiment investigated whether sex and/or different prenatal treatment conditions would influence commissural size at birth. Male and female 3-day-old Long Evans rats were selected from one of three prenatal treatment histories: prenatal alcohol-exposed (35% ethanol-derived calories, 35% EDC), nutritional control (0% ethanol-derived calories, 0% EDC) or standard control (lab chow). Midline sagittal areas of the corpus callosum and the anterior commissure were determined for these subjects. Male control subjects had significantly larger callosal areas than females. Prenatal alcohol exposure significantly abolished this sexual dimorphism, with 35% EDC males having a significantly smaller callosal area than males from both control groups. This effect was independent of prenatal treatment differences in body or brain size. There were no significant sex differences in the midline sagittal area of the anterior commissure, nor were there any apparent effects of prenatal treatment on this measure. These results indicate that sex differences in the size of the corpus callosum are present at birth. Since a difference in myelination cannot account for this difference in area, there may be a sex difference in the number of fibers or in the average fiber size. Additionally, the effects of prenatal alcohol exposure on male, but not female, offspring suggest that this alcohol-related birth defect is hormonally mediated.

UR - http://www.scopus.com/inward/record.url?scp=0024496028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024496028&partnerID=8YFLogxK

U2 - 10.1016/0736-5748(89)90046-4

DO - 10.1016/0736-5748(89)90046-4

M3 - Article

VL - 7

SP - 81

EP - 86

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

IS - 1

ER -