Using database screening techniques we have examined the relationship between antigen‐binding loops in immunoglobulins, and regions of similar conformation in other protein families. The conformations of most antigen‐binding loops are not unique to immunoglobulins. But in many cases, the geometrical relationship between the loop and the peptides flanking it differs between the immunoglobulins and other structures with the same loop. We assess model building by data base screening, compared with thatbased on canonical structures. © 1992 Wiley‐Liss, Inc.
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology