Abstract
The study tested the hypothesis that variation in the oxytocin receptor gene (OXTR rs53576) and self-report of rejection sensitivity are associated with adrenocortical reactivity to social stress. Participants (N=94; 36.17% male; Mage=20.18yrs; 62.8% Caucasian) completed a writing task on a salient problem in society, provided self-report via questionnaire of rejection sensitivity, and were then informed that a committee of peers would evaluate their written comments. Participants received either scripted praise or criticism as a way to induce social evaluative threat. Saliva was collected before and after the stress task and assayed for cortisol. Results revealed that cortisol levels increased in participants with moderate levels of social rejection sensitivity-inferred by rs53576 genotype and reported rejection sensitivity-while cortisol levels decreased in participants with high and low levels of social rejection sensitivity. Our findings suggest a curvilinear relationship between social rejection sensitivity and cortisol reactivity in the context of social rejection, warranting further consideration in future studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 64-69 |
| Number of pages | 6 |
| Journal | Hormones and Behavior |
| Volume | 75 |
| DOIs | |
| State | Published - Sep 1 2015 |
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All Science Journal Classification (ASJC) codes
- Endocrinology
- Endocrine and Autonomic Systems
- Behavioral Neuroscience
Cite this
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Common oxytocin receptor gene variant interacts with rejection sensitivity to influence cortisol reactivity during negative evaluation. / Auer, Brandon; Byrd-Craven, Jennifer; Grant, De Mond M.; Granger, Douglas A.
In: Hormones and Behavior, Vol. 75, 01.09.2015, p. 64-69.Research output: Contribution to journal › Article
TY - JOUR
T1 - Common oxytocin receptor gene variant interacts with rejection sensitivity to influence cortisol reactivity during negative evaluation
AU - Auer, Brandon
AU - Byrd-Craven, Jennifer
AU - Grant, De Mond M.
AU - Granger, Douglas A.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The study tested the hypothesis that variation in the oxytocin receptor gene (OXTR rs53576) and self-report of rejection sensitivity are associated with adrenocortical reactivity to social stress. Participants (N=94; 36.17% male; Mage=20.18yrs; 62.8% Caucasian) completed a writing task on a salient problem in society, provided self-report via questionnaire of rejection sensitivity, and were then informed that a committee of peers would evaluate their written comments. Participants received either scripted praise or criticism as a way to induce social evaluative threat. Saliva was collected before and after the stress task and assayed for cortisol. Results revealed that cortisol levels increased in participants with moderate levels of social rejection sensitivity-inferred by rs53576 genotype and reported rejection sensitivity-while cortisol levels decreased in participants with high and low levels of social rejection sensitivity. Our findings suggest a curvilinear relationship between social rejection sensitivity and cortisol reactivity in the context of social rejection, warranting further consideration in future studies.
AB - The study tested the hypothesis that variation in the oxytocin receptor gene (OXTR rs53576) and self-report of rejection sensitivity are associated with adrenocortical reactivity to social stress. Participants (N=94; 36.17% male; Mage=20.18yrs; 62.8% Caucasian) completed a writing task on a salient problem in society, provided self-report via questionnaire of rejection sensitivity, and were then informed that a committee of peers would evaluate their written comments. Participants received either scripted praise or criticism as a way to induce social evaluative threat. Saliva was collected before and after the stress task and assayed for cortisol. Results revealed that cortisol levels increased in participants with moderate levels of social rejection sensitivity-inferred by rs53576 genotype and reported rejection sensitivity-while cortisol levels decreased in participants with high and low levels of social rejection sensitivity. Our findings suggest a curvilinear relationship between social rejection sensitivity and cortisol reactivity in the context of social rejection, warranting further consideration in future studies.
UR - http://www.scopus.com/inward/record.url?scp=84938805319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938805319&partnerID=8YFLogxK
U2 - 10.1016/j.yhbeh.2015.07.023
DO - 10.1016/j.yhbeh.2015.07.023
M3 - Article
VL - 75
SP - 64
EP - 69
JO - Hormones and Behavior
JF - Hormones and Behavior
SN - 0018-506X
ER -