Communal nesting increases pup growth but has limited effects on adult behavior and neurophysiology in inbred mice

Kathleen M. Heiderstadt, David J. Vandenbergh, Joseph P. Gyekis, David A. Blizard

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Laboratory mice preferentially rear their offspring in communal nests (CN), with all mothers contributing to maternal care and feeding of all the pups. Previous studies using primarily outbred mice have shown that offspring reared under CN conditions may display increased preweaning growth rates and differences in adult behavior and neurobiology compared with mice reared under single-nesting (SN; one dam with her litter) conditions. Here we compared pup mortality; weaning and adult body weights; adult behavior; and gene expression in the hippocampus and frontal cortex between C57BL/6J, DBA/2J and 129x1/SvJ mice reared by using CN (3 dams and their litters sharing a single nest) or SN. Male and female pups of all 3 strains reared in CN cages showed higher body weight at weaning than did SN pups of the same strain, with no significant difference in pup mortality between groups. Adult male offspring reared in CN showed no differences in any behavioral test when compared with SN offspring. Combining CN dams and litters after parturition revealed greater cortical brain-derived neurotropic factor expression in adult male C57BL/6J offspring and cortical glucocorticoid receptor expression in adult male C57BL/6J and 129x1/SvJ offspring as compared with SN offspring of the same strain. Communal rearing can enhance juvenile growth rates but does not change adult behavior in inbred mouse strains, although potential effects on adult neurophysiology are possible.

Original languageEnglish (US)
Pages (from-to)152-160
Number of pages9
JournalJournal of the American Association for Laboratory Animal Science
Volume53
Issue number2
StatePublished - Mar 2014

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neurophysiology
pups
nests
mice
litters (young animals)
weaning
body weight
hippocampus
cages
rearing
parturition
brain
gene expression

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

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title = "Communal nesting increases pup growth but has limited effects on adult behavior and neurophysiology in inbred mice",
abstract = "Laboratory mice preferentially rear their offspring in communal nests (CN), with all mothers contributing to maternal care and feeding of all the pups. Previous studies using primarily outbred mice have shown that offspring reared under CN conditions may display increased preweaning growth rates and differences in adult behavior and neurobiology compared with mice reared under single-nesting (SN; one dam with her litter) conditions. Here we compared pup mortality; weaning and adult body weights; adult behavior; and gene expression in the hippocampus and frontal cortex between C57BL/6J, DBA/2J and 129x1/SvJ mice reared by using CN (3 dams and their litters sharing a single nest) or SN. Male and female pups of all 3 strains reared in CN cages showed higher body weight at weaning than did SN pups of the same strain, with no significant difference in pup mortality between groups. Adult male offspring reared in CN showed no differences in any behavioral test when compared with SN offspring. Combining CN dams and litters after parturition revealed greater cortical brain-derived neurotropic factor expression in adult male C57BL/6J offspring and cortical glucocorticoid receptor expression in adult male C57BL/6J and 129x1/SvJ offspring as compared with SN offspring of the same strain. Communal rearing can enhance juvenile growth rates but does not change adult behavior in inbred mouse strains, although potential effects on adult neurophysiology are possible.",
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Communal nesting increases pup growth but has limited effects on adult behavior and neurophysiology in inbred mice. / Heiderstadt, Kathleen M.; Vandenbergh, David J.; Gyekis, Joseph P.; Blizard, David A.

In: Journal of the American Association for Laboratory Animal Science, Vol. 53, No. 2, 03.2014, p. 152-160.

Research output: Contribution to journalArticle

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