Community influenza activity and risk of acute influenza-like illness episodes among healthy unvaccinated pregnant and postpartum women

Lisa Lindsay, Lisa A. Jackson, David A. Savitz, David J. Weber, Gary G. Koch, Lan Kong, Harry A. Guess

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

This study investigated the relation between weekly levels of influenza activity and the risk of acute influenza-like illness episodes among 8,323 healthy pregnant and postpartum women enrolled in a Puget Sound region, Washington, health maintenance organization, Group Health Cooperative, between June 1991 and December 1997. The authors classified weeks between October and May for isolate activity level based on surveillance data for influenza, respiratory syncytial virus, parainfluenza, and adenovirus infection. Influenza-like illness episodes were identified from medical encounters assigned a diagnostic code consistent with a symptomatic influenza infection. The authors compared the occurrence of influenza-like illness episodes within each pregnancy stage for periods with varying levels of influenza isolate detection in the community. Repeated-measures logistic regression methods accounted for time-dependent factors. The adjusted strength of association between influenza exposure and influenza-like illness episodes increased as the pregnancy stage progressed (first trimester odds ratio = 1.12, 95% confidence interval: 0.79, 1.59; second trimester odds ratio = 1.30, 95% confidence interval: 0.97, 1.73; third trimester odds ratio = 1.84, 95% confidence interval: 1.31, 2.59; postpartum period odds ratio = 2.28, 95% confidence interval: 1.42, 3.68). Pregnancy stage modified the association between influenza activity and influenza-like illness episodes. Findings estimate that 20-43 pregnant/postpartum women would need to be vaccinated with an 80% effective vaccine to prevent one influenza-like illness episode.

Original languageEnglish (US)
Pages (from-to)838-848
Number of pages11
JournalAmerican journal of epidemiology
Volume163
Issue number9
DOIs
StatePublished - May 11 2006

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Postpartum Period
Human Influenza
Pregnant Women
Odds Ratio
Confidence Intervals
Pregnancy
Adenoviridae Infections
Paramyxoviridae Infections
Respiratory Syncytial Virus Infections
Health Maintenance Organizations
Third Pregnancy Trimester
Second Pregnancy Trimester
First Pregnancy Trimester
Vaccines
Logistic Models

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Lindsay, Lisa ; Jackson, Lisa A. ; Savitz, David A. ; Weber, David J. ; Koch, Gary G. ; Kong, Lan ; Guess, Harry A. / Community influenza activity and risk of acute influenza-like illness episodes among healthy unvaccinated pregnant and postpartum women. In: American journal of epidemiology. 2006 ; Vol. 163, No. 9. pp. 838-848.
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Community influenza activity and risk of acute influenza-like illness episodes among healthy unvaccinated pregnant and postpartum women. / Lindsay, Lisa; Jackson, Lisa A.; Savitz, David A.; Weber, David J.; Koch, Gary G.; Kong, Lan; Guess, Harry A.

In: American journal of epidemiology, Vol. 163, No. 9, 11.05.2006, p. 838-848.

Research output: Contribution to journalArticle

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