Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer

Ming Yin, Jing Zhao, Paul Monk, Douglas Martin, Edmund Folefac, Monika Joshi, Ning Jin, Amir Mortazavi, Claire Verschraegen, Steven Clinton

Research output: Contribution to journalArticle

Abstract

Background: It remains controversial if radical prostatectomy or definitive radiation therapy produces equivalent outcomes in high-risk localized prostate cancer. Methods: We queried The Surveillance, Epidemiology, and End Results (SEER) database for those who received upfront surgery or who were recommended for surgery but instead received radiation. Inverse probability of treatment weighing was used to adjust for covariate imbalance and the weighted Cox proportional hazards model was used to estimate the effects of treatment groups on survival. A meta-analysis was performed to pool estimates from published studies. Results: Among eligible 62 533 patients, 59 540 had upfront surgery and 2993 patients had upfront radiotherapy. EBRT + BT was associated with a superior cancer-specific survival (CSS) compared with surgery or EBRT alone (HR, 0.55, 95% CI, 0.3-1.0; HR, 0.49, 95% CI, 0.24-0.98, respectively), whereas EBRT was associated with an inferior overall survival (OS) compared with surgery (HR, 1.46, 95% CI, 1.16-1.8). Radiotherapy (EBRT ± BT) was inferior to surgery by OS (HR, 1.63, 95% CI, 1.13-2.34) in patients ≤ 65 years, and was superior to surgery by CSS in patients > 65 years (HR, 0.69, 95% CI, 0.49-0.97). The meta-analysis showed consistent results. Conclusion: EBRT + BT was associated with a significantly better prostate CSS compared with surgery or EBRT. EBRT alone was inferior to surgery by OS.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalCancer medicine
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2020

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Brachytherapy
Prostatic Neoplasms
Radiation
Survival
Radiotherapy
Meta-Analysis
Prostatectomy
Proportional Hazards Models
Neoplasms
Epidemiology
Databases
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Yin, Ming ; Zhao, Jing ; Monk, Paul ; Martin, Douglas ; Folefac, Edmund ; Joshi, Monika ; Jin, Ning ; Mortazavi, Amir ; Verschraegen, Claire ; Clinton, Steven. / Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer. In: Cancer medicine. 2020 ; Vol. 9, No. 1. pp. 27-34.
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abstract = "Background: It remains controversial if radical prostatectomy or definitive radiation therapy produces equivalent outcomes in high-risk localized prostate cancer. Methods: We queried The Surveillance, Epidemiology, and End Results (SEER) database for those who received upfront surgery or who were recommended for surgery but instead received radiation. Inverse probability of treatment weighing was used to adjust for covariate imbalance and the weighted Cox proportional hazards model was used to estimate the effects of treatment groups on survival. A meta-analysis was performed to pool estimates from published studies. Results: Among eligible 62 533 patients, 59 540 had upfront surgery and 2993 patients had upfront radiotherapy. EBRT + BT was associated with a superior cancer-specific survival (CSS) compared with surgery or EBRT alone (HR, 0.55, 95{\%} CI, 0.3-1.0; HR, 0.49, 95{\%} CI, 0.24-0.98, respectively), whereas EBRT was associated with an inferior overall survival (OS) compared with surgery (HR, 1.46, 95{\%} CI, 1.16-1.8). Radiotherapy (EBRT ± BT) was inferior to surgery by OS (HR, 1.63, 95{\%} CI, 1.13-2.34) in patients ≤ 65 years, and was superior to surgery by CSS in patients > 65 years (HR, 0.69, 95{\%} CI, 0.49-0.97). The meta-analysis showed consistent results. Conclusion: EBRT + BT was associated with a significantly better prostate CSS compared with surgery or EBRT. EBRT alone was inferior to surgery by OS.",
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Yin, M, Zhao, J, Monk, P, Martin, D, Folefac, E, Joshi, M, Jin, N, Mortazavi, A, Verschraegen, C & Clinton, S 2020, 'Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer', Cancer medicine, vol. 9, no. 1, pp. 27-34. https://doi.org/10.1002/cam4.2605

Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer. / Yin, Ming; Zhao, Jing; Monk, Paul; Martin, Douglas; Folefac, Edmund; Joshi, Monika; Jin, Ning; Mortazavi, Amir; Verschraegen, Claire; Clinton, Steven.

In: Cancer medicine, Vol. 9, No. 1, 01.01.2020, p. 27-34.

Research output: Contribution to journalArticle

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T1 - Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer

AU - Yin, Ming

AU - Zhao, Jing

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AU - Joshi, Monika

AU - Jin, Ning

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AU - Verschraegen, Claire

AU - Clinton, Steven

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N2 - Background: It remains controversial if radical prostatectomy or definitive radiation therapy produces equivalent outcomes in high-risk localized prostate cancer. Methods: We queried The Surveillance, Epidemiology, and End Results (SEER) database for those who received upfront surgery or who were recommended for surgery but instead received radiation. Inverse probability of treatment weighing was used to adjust for covariate imbalance and the weighted Cox proportional hazards model was used to estimate the effects of treatment groups on survival. A meta-analysis was performed to pool estimates from published studies. Results: Among eligible 62 533 patients, 59 540 had upfront surgery and 2993 patients had upfront radiotherapy. EBRT + BT was associated with a superior cancer-specific survival (CSS) compared with surgery or EBRT alone (HR, 0.55, 95% CI, 0.3-1.0; HR, 0.49, 95% CI, 0.24-0.98, respectively), whereas EBRT was associated with an inferior overall survival (OS) compared with surgery (HR, 1.46, 95% CI, 1.16-1.8). Radiotherapy (EBRT ± BT) was inferior to surgery by OS (HR, 1.63, 95% CI, 1.13-2.34) in patients ≤ 65 years, and was superior to surgery by CSS in patients > 65 years (HR, 0.69, 95% CI, 0.49-0.97). The meta-analysis showed consistent results. Conclusion: EBRT + BT was associated with a significantly better prostate CSS compared with surgery or EBRT. EBRT alone was inferior to surgery by OS.

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