Comparative Effects of postnatal undernutrition and methadone exposure on protein and nucleic acid contents of the brain and cerebellum in rats

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Abstract

The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH rats had the most severe deficits in the weight and total DNA content of the brain and cerebellum, as well as in brain DNA concentration. All experimental rats were subnormal in body weight at 60 days, as was the brain weight of METH-UND rats. Total brain DNA content was most reduced in 60-day-old METH animals, whereas brain RNA content and cerebellar DNA content was only lower in UND and METH-UND animals. These results suggest that methadone often has a greater retarding effect on whole brain and cerebellar development than would be expected by reduced caloric intake alone, and that at least part of the growth inhibiting effects of this drug originates from nonnutritional causes.

Original languageEnglish (US)
Pages (from-to)385-393
Number of pages9
JournalDevelopmental Neuroscience
Volume5
Issue number5-6
DOIs
StatePublished - Jan 1 1982

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Methadone
Malnutrition
Cerebellum
Nucleic Acids
Brain
Proteins
DNA
Body Weight
Weights and Measures
Energy Intake
Weight Loss
RNA
Growth

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

Cite this

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abstract = "The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH rats had the most severe deficits in the weight and total DNA content of the brain and cerebellum, as well as in brain DNA concentration. All experimental rats were subnormal in body weight at 60 days, as was the brain weight of METH-UND rats. Total brain DNA content was most reduced in 60-day-old METH animals, whereas brain RNA content and cerebellar DNA content was only lower in UND and METH-UND animals. These results suggest that methadone often has a greater retarding effect on whole brain and cerebellar development than would be expected by reduced caloric intake alone, and that at least part of the growth inhibiting effects of this drug originates from nonnutritional causes.",
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