Comparative electromechanical and hemodynamic effects of left ventricular and biventricular pacing in dyssynchronous heart failure: Electrical resynchronization versus left-right ventricular interaction

Joost Lumens, Sylvain Ploux, Marc Strik, John Gorcsan, Hubert Cochet, Nicolas Derval, Maria Strom, Charu Ramanathan, Philippe Ritter, Michel Haïssaguerre, Pierre Jaïs, Theo Arts, Tammo Delhaas, Frits W. Prinzen, Pierre Bordachar

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives The purpose of this study was to enhance understanding of the working mechanism of cardiac resynchronization therapy by comparing animal experimental, clinical, and computational data on the hemodynamic and electromechanical consequences of left ventricular pacing (LVP) and biventricular pacing (BiVP). Background It is unclear why LVP and BiVP have comparative positive effects on hemodynamic function of patients with dyssynchronous heart failure. Methods Hemodynamic response to LVP and BiVP (% change in maximal rate of left ventricular pressure rise [LVdP/dt max]) was measured in 6 dogs and 24 patients with heart failure and left bundle branch block followed by computer simulations of local myofiber mechanics during LVP and BiVP in the failing heart with left bundle branch block. Pacing-induced changes of electrical activation were measured in dogs using contact mapping and in patients using a noninvasive multielectrode electrocardiographic mapping technique. Results LVP and BiVP similarly increased LVdP/dtmax in dogs and in patients, but only BiVP significantly decreased electrical dyssynchrony. In the simulations, LVP and BiVP increased total ventricular myofiber work to the same extent. While the LVP-induced increase was entirely due to enhanced right ventricular (RV) myofiber work, the BiVP-induced increase was due to enhanced myofiber work of both the left ventricle (LV) and RV. Overall, LVdP/dtmax correlated better with total ventricular myofiber work than with LV or RV myofiber work alone. Conclusions Animal experimental, clinical, and computational data support the similarity of hemodynamic response to LVP and BiVP, despite differences in electrical dyssynchrony. The simulations provide the novel insight that, through ventricular interaction, the RV myocardium importantly contributes to the improvement in LV pump function induced by cardiac resynchronization therapy.

Original languageEnglish (US)
Pages (from-to)2395-2403
Number of pages9
JournalJournal of the American College of Cardiology
Volume62
Issue number25
DOIs
StatePublished - Dec 24 2013

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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