Abstract

The genomes from three mammals (human, mouse, and rat), two worms, and several yeasts have been sequenced, and more genomes will be completed in the near future for comparison with those of the major model organisms. Scientists have used various methods to align and compare the sequenced genomes to address critical issues in genome function and evolution. This review covers some of the major new insights about gene content, gene regulation, and the fraction of mammalian genomes that are under purifying selection and presumed functional. We review the evolutionary processes that shape genomes, with particular attention to variation in rates within genomes and along different lineages. Internet resources for accessing and analyzing the treasure trove of sequence alignments and annotations are reviewed, and we discuss critical problems to address in new bioinformatic developments in comparative genomics.

Original languageEnglish (US)
Pages (from-to)15-56
Number of pages42
JournalAnnual Review of Genomics and Human Genetics
Volume5
DOIs
StatePublished - Oct 25 2004

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Genomics
Genome
Sequence Alignment
Computational Biology
Internet
Genes
Mammals
Yeasts

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

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title = "Comparative genomics",
abstract = "The genomes from three mammals (human, mouse, and rat), two worms, and several yeasts have been sequenced, and more genomes will be completed in the near future for comparison with those of the major model organisms. Scientists have used various methods to align and compare the sequenced genomes to address critical issues in genome function and evolution. This review covers some of the major new insights about gene content, gene regulation, and the fraction of mammalian genomes that are under purifying selection and presumed functional. We review the evolutionary processes that shape genomes, with particular attention to variation in rates within genomes and along different lineages. Internet resources for accessing and analyzing the treasure trove of sequence alignments and annotations are reviewed, and we discuss critical problems to address in new bioinformatic developments in comparative genomics.",
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journal = "Annual Review of Genomics and Human Genetics",
issn = "1527-8204",
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Comparative genomics. / Miller, Webb; Makova, Kateryna Dmytrivna; Nekrutenko, Anton; Hardison, Ross Cameron.

In: Annual Review of Genomics and Human Genetics, Vol. 5, 25.10.2004, p. 15-56.

Research output: Contribution to journalReview article

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AU - Miller, Webb

AU - Makova, Kateryna Dmytrivna

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AU - Hardison, Ross Cameron

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AB - The genomes from three mammals (human, mouse, and rat), two worms, and several yeasts have been sequenced, and more genomes will be completed in the near future for comparison with those of the major model organisms. Scientists have used various methods to align and compare the sequenced genomes to address critical issues in genome function and evolution. This review covers some of the major new insights about gene content, gene regulation, and the fraction of mammalian genomes that are under purifying selection and presumed functional. We review the evolutionary processes that shape genomes, with particular attention to variation in rates within genomes and along different lineages. Internet resources for accessing and analyzing the treasure trove of sequence alignments and annotations are reviewed, and we discuss critical problems to address in new bioinformatic developments in comparative genomics.

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