Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus

Yixin H. Ye, Tat Siong Ng, Francesca D. Frentiu, Thomas Walker, Andrew F. Van Den Hurk, Scott L. O'Neill, Nigel W. Beebe, Elizabeth A. McGraw

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases. We compared the susceptibility of Aedes aegypti mosquitoes from two geographically isolated populations to two strains of dengue virus serotype 2. We found, interestingly, that mosquitoes from a city with no history of dengue were more susceptible to virus than mosquitoes from an outbreak-prone region, particularly with respect to one dengue strain. These findings suggest recent evolution of population-based differences in vector competence or different historical origins. Future genomic comparisons of these populations could reveal the genetic basis of vector competence and the relative role of selection and stochastic processes in shaping their differences. Lastly, we show the novel finding of a correlation between midgut dengue titer and titer in tissues colonized after dissemination.

Original languageEnglish (US)
Pages (from-to)422-430
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume90
Issue number3
DOIs
StatePublished - Mar 2014

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

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