Comparative Tumorigenicity of 1-Nitropyrene, 1-Nitrosopyrene, and 1-Aminopyrene Administered by Gavage to Sprague-Dawley Rats

Karam El-Bayoumy, Abraham Rivenson, Bruce Johnson, Joann DiBello, Patricia Little, Stephen S. Hecht

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Abstract

The carcinogenic activities of 1-nitropyrene, a mutagenic component of diesel exhaust, and its reduced derivatives 1-nitrosopyrene and 1-aminopyrene were evaluated in male and female Sprague-Dawley rats. Within 24 h of birth, groups of 22–36 rats were treated by gavage with trioctanoin or the appropriate compound in trioctanoin once weekly for 16 weeks. The approximate total doses per rat were as follows: 1-nitropyrene, high dose (800 μmol); 1-nitropyrene, low dose (320 μmol); 1-nitrosopyrene (320 μmol); 1-aminopyrene (320 μmol). The experiment was terminated after 94 weeks. The main site of tumor induction was the mammary glands of female rats. Percentages of incidences of mammary adenocarcinomas in female rats were as follows: 1-nitropyrene, high dose (63%); 1-nitropyrene, low dose (42%); 1-nitrosopyrene (19%); 1-aminopyrene (4%); trioctanoin (3%). These incidences were significantly greater than those of controls for the female rats treated with either 1-nitropyrene or 1-nitrosopyrene. Low and generally insignificant incidences of tumors of a variety of other sites were also observed in rats treated with 1-nitropyrene. The induction of mammary tumors by 1-nitropyrene confirms the results of a previous study (Hirose et al., Cancer Res., 44: 1158–1162, 1984). The present results also demonstrate that, under the conditions of this bioassay, 1-nitropyrene was significantly more carcinogenic than either 1-nitrosopyrene or 1-aminopyrene.

Original languageEnglish (US)
Pages (from-to)4256-4260
Number of pages5
JournalCancer Research
Volume48
Issue number15
StatePublished - 1988

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1-nitropyrene
Sprague Dawley Rats
Incidence
1-nitrosopyrene
1-aminopyrene
Vehicle Emissions
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

El-Bayoumy, Karam ; Rivenson, Abraham ; Johnson, Bruce ; DiBello, Joann ; Little, Patricia ; Hecht, Stephen S. / Comparative Tumorigenicity of 1-Nitropyrene, 1-Nitrosopyrene, and 1-Aminopyrene Administered by Gavage to Sprague-Dawley Rats. In: Cancer Research. 1988 ; Vol. 48, No. 15. pp. 4256-4260.
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title = "Comparative Tumorigenicity of 1-Nitropyrene, 1-Nitrosopyrene, and 1-Aminopyrene Administered by Gavage to Sprague-Dawley Rats",
abstract = "The carcinogenic activities of 1-nitropyrene, a mutagenic component of diesel exhaust, and its reduced derivatives 1-nitrosopyrene and 1-aminopyrene were evaluated in male and female Sprague-Dawley rats. Within 24 h of birth, groups of 22–36 rats were treated by gavage with trioctanoin or the appropriate compound in trioctanoin once weekly for 16 weeks. The approximate total doses per rat were as follows: 1-nitropyrene, high dose (800 μmol); 1-nitropyrene, low dose (320 μmol); 1-nitrosopyrene (320 μmol); 1-aminopyrene (320 μmol). The experiment was terminated after 94 weeks. The main site of tumor induction was the mammary glands of female rats. Percentages of incidences of mammary adenocarcinomas in female rats were as follows: 1-nitropyrene, high dose (63{\%}); 1-nitropyrene, low dose (42{\%}); 1-nitrosopyrene (19{\%}); 1-aminopyrene (4{\%}); trioctanoin (3{\%}). These incidences were significantly greater than those of controls for the female rats treated with either 1-nitropyrene or 1-nitrosopyrene. Low and generally insignificant incidences of tumors of a variety of other sites were also observed in rats treated with 1-nitropyrene. The induction of mammary tumors by 1-nitropyrene confirms the results of a previous study (Hirose et al., Cancer Res., 44: 1158–1162, 1984). The present results also demonstrate that, under the conditions of this bioassay, 1-nitropyrene was significantly more carcinogenic than either 1-nitrosopyrene or 1-aminopyrene.",
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El-Bayoumy, K, Rivenson, A, Johnson, B, DiBello, J, Little, P & Hecht, SS 1988, 'Comparative Tumorigenicity of 1-Nitropyrene, 1-Nitrosopyrene, and 1-Aminopyrene Administered by Gavage to Sprague-Dawley Rats', Cancer Research, vol. 48, no. 15, pp. 4256-4260.

Comparative Tumorigenicity of 1-Nitropyrene, 1-Nitrosopyrene, and 1-Aminopyrene Administered by Gavage to Sprague-Dawley Rats. / El-Bayoumy, Karam; Rivenson, Abraham; Johnson, Bruce; DiBello, Joann; Little, Patricia; Hecht, Stephen S.

In: Cancer Research, Vol. 48, No. 15, 1988, p. 4256-4260.

Research output: Contribution to journalArticle

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T1 - Comparative Tumorigenicity of 1-Nitropyrene, 1-Nitrosopyrene, and 1-Aminopyrene Administered by Gavage to Sprague-Dawley Rats

AU - El-Bayoumy, Karam

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AU - Little, Patricia

AU - Hecht, Stephen S.

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N2 - The carcinogenic activities of 1-nitropyrene, a mutagenic component of diesel exhaust, and its reduced derivatives 1-nitrosopyrene and 1-aminopyrene were evaluated in male and female Sprague-Dawley rats. Within 24 h of birth, groups of 22–36 rats were treated by gavage with trioctanoin or the appropriate compound in trioctanoin once weekly for 16 weeks. The approximate total doses per rat were as follows: 1-nitropyrene, high dose (800 μmol); 1-nitropyrene, low dose (320 μmol); 1-nitrosopyrene (320 μmol); 1-aminopyrene (320 μmol). The experiment was terminated after 94 weeks. The main site of tumor induction was the mammary glands of female rats. Percentages of incidences of mammary adenocarcinomas in female rats were as follows: 1-nitropyrene, high dose (63%); 1-nitropyrene, low dose (42%); 1-nitrosopyrene (19%); 1-aminopyrene (4%); trioctanoin (3%). These incidences were significantly greater than those of controls for the female rats treated with either 1-nitropyrene or 1-nitrosopyrene. Low and generally insignificant incidences of tumors of a variety of other sites were also observed in rats treated with 1-nitropyrene. The induction of mammary tumors by 1-nitropyrene confirms the results of a previous study (Hirose et al., Cancer Res., 44: 1158–1162, 1984). The present results also demonstrate that, under the conditions of this bioassay, 1-nitropyrene was significantly more carcinogenic than either 1-nitrosopyrene or 1-aminopyrene.

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