Compared with dba/2j mice, c57bl/6j mice demonstrate greater preference for saccharin and less avoidance of a cocaine-paired saccharin cue

Christopher Freet, Amanda Arndt, Patricia "Sue" Grigson-Kennedy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Rats avoid intake of a saccharin cue when paired with a drug of abuse. While this is true for most subjects, the degree of avoidance of the drug-paired cue depends upon many factors including an individual rat's preference for rewards. That said, the direction of this effect is complex. For example, reward-preferring Lewis rats exhibit greater cocaine-induced avoidance of a saccharin cue relative to Fischer 344 rats; while reward-preferring mice that overexpress δFosB (NSE-tTA × TetOp-δFosB) exhibit less avoidance of the drug-paired taste cue compared to controls. The aim here was to use two strains of commonly used mice, C57BL/6J and DBA/2J, to determine whether known differences in sensitivity to rewards will facilitate or attenuate drug-induced suppression of intake of a drug-paired taste cue. The results of Experiment 1 demonstrate that C57BL/6J mice, compared with DBA/2J mice, exhibit attenuated suppression of saccharin intake when it is paired with cocaine. The results of Experiment 2 demonstrate that strain differences in impulsivity are not likely to account for these differences. It is proposed that, while the C57BL/6J mice typically are more responsive to drug, they also are more responsive to natural rewards (in this case saccharin), and the stronger preference for saccharin serves to militate against drug.

Original languageEnglish (US)
Pages (from-to)474-484
Number of pages11
JournalBehavioral Neuroscience
Volume127
Issue number3
DOIs
StatePublished - Jun 1 2013

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Saccharin
Cocaine
Cues
Reward
Inbred C57BL Mouse
Pharmaceutical Preparations
Inbred DBA Mouse
Impulsive Behavior
Inbred F344 Rats
Street Drugs

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

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Compared with dba/2j mice, c57bl/6j mice demonstrate greater preference for saccharin and less avoidance of a cocaine-paired saccharin cue. / Freet, Christopher; Arndt, Amanda; Grigson-Kennedy, Patricia "Sue".

In: Behavioral Neuroscience, Vol. 127, No. 3, 01.06.2013, p. 474-484.

Research output: Contribution to journalArticle

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