Comparing salt appetites: Induction with intracranial hormones or dietary sodium restriction

Madhavi R. Prakash, Ralph Norgren

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To raise a natural sodium appetite in the laboratory requires approximately 10 days on a very low sodium diet. Most other regimens induce sodium appetite more rapidly, but also result in behavioral or physiological changes not observed in the deprivation-induced state. We compared the characteristics of need-free sodium appetite induced either by systemic aldosterone combined with an intracerebroventricular (ICV) injection of angiotensin II or by a single ICV injection of renin with an appetite induced by 10 days of sodium deprivation. We measured the latency to drink water and 3% NaCl, as well as the amount of these fluids consumed at 30 min, 3 h, and 24 h. Angiotensin induced the shortest latency for both water and salt drinking, but the overall salt intake was lower. In 24 h, renin and sodium deprivation both induced about 14 ml of NaCl consumption, but the time course of the fluid intake differed for the two regimens.

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalBrain Research Bulletin
Volume27
Issue number3-4
DOIs
StatePublished - Jan 1 1991

Fingerprint

Dietary Sodium
Appetite
Salts
Sodium
Hormones
Renin
Sodium-Restricted Diet
Injections
Angiotensins
Aldosterone
Angiotensin II
Drinking Water
Water

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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abstract = "To raise a natural sodium appetite in the laboratory requires approximately 10 days on a very low sodium diet. Most other regimens induce sodium appetite more rapidly, but also result in behavioral or physiological changes not observed in the deprivation-induced state. We compared the characteristics of need-free sodium appetite induced either by systemic aldosterone combined with an intracerebroventricular (ICV) injection of angiotensin II or by a single ICV injection of renin with an appetite induced by 10 days of sodium deprivation. We measured the latency to drink water and 3{\%} NaCl, as well as the amount of these fluids consumed at 30 min, 3 h, and 24 h. Angiotensin induced the shortest latency for both water and salt drinking, but the overall salt intake was lower. In 24 h, renin and sodium deprivation both induced about 14 ml of NaCl consumption, but the time course of the fluid intake differed for the two regimens.",
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Comparing salt appetites : Induction with intracranial hormones or dietary sodium restriction. / Prakash, Madhavi R.; Norgren, Ralph.

In: Brain Research Bulletin, Vol. 27, No. 3-4, 01.01.1991, p. 397-401.

Research output: Contribution to journalArticle

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