Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity

W. O. Cook, V. R. Beasley, A. M. Dahlem, J. A. Dellinger, K. S. Harlin, W. W. Carmichael

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Comparison of effects of anatoxin-a(s) and paraoxon, physostigmine and pyridostigmine on mouse brain cholinesterase activity. Toxicon 26, 750 - 753, 1988. - Anatoxin-a(s), an alkaloid neurotoxin from the freshwater cyanobacterium, Anabaena flos-aquae NRC-525-17, was compared to paraoxon, physostigmine and pyridostigmine for effects on brain cholinesterase after i.p. injection into Balb/c mice. The duration of clinical signs in mice injected with anatoxin-a(s) persisted longer than in mice given the carbamates and was comparable with that of paraoxon. Anatoxin-a(s) did not inhibit brain cholinesterase activity suggesting that this toxin is unable to cross the blood - brain barrier.

Original languageEnglish (US)
Pages (from-to)750-753
Number of pages4
JournalToxicon
Volume26
Issue number8
DOIs
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Toxicology

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