Comparison of hemolysis between centrimag and rotaflow rotary blood pumps during extracorporeal membrane oxygenation

David A. Palanzo, Aly El-Banayosy, Edward Stephenson, Christoph Brehm, Allen Kunselman, Walter Pae

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The purpose of this investigation was to compare the hemolysis levels for patients on extracorporeal membrane oxygenation (ECMO) incorporating two different rotary blood pumps (CentriMag [CMAG] and RotaFlow [RF]) in identical circuits otherwise. The difference between the two pumps is the cost. One is 20-30 times less expensive than the other. A retrospective analysis of all patients placed on ECMO from June 2008 through May 2012 was done to evaluate hemolysis. Daily plasma hemoglobin (pHb), lactate dehydrogenase (LDH), and lactate levels were collected on all patients. Values were compared between those patients who received a CMAG and those who received an RF. Patients had to be on ECMO for more than 2 days to be included in the study. Linear mixed effects models were fit to the data to assess differences over time for each continuous outcome. Forty patients were placed on ECMO incorporating CMAG, whereas 40 patients received an RF. There were no significant statistical differences between CMAG and RF groups when comparing days on support (8.7±5.0; 8.4±5.7), age (44.8±18.3; 46.1±16.0), body surface area (2.03±0.36; 1.96±0.31), gender (male: 58%, female: 42%; male: 55%, female: 45%), etiology, type of support (veno-arterial [VA)]: 78%, veno-venous [VV)]: 22%; VA: 82%, VV: 18%) and pre-ECMO LDH levels (4004.0±3583.2; 3603.7±3354.1). There were also no significant differences between the CMAG and RF groups when comparing the mean values for daily pHb levels (5.7±3.6; 5.7±4.2), lactate levels (2.8±1.9; 3.0±2.1), and LDH levels (2656.3±1606.8; 2688.6±1726.1) or daily lactate, LDH, and pHb levels for the first 10 days of support. From our investigation, there is no difference between the CMAG and the RF blood pumps in regard to the creation of hemolysis during ECMO. The difference in cost of the devices does not correlate with the performance and outcomes.

Original languageEnglish (US)
JournalArtificial Organs
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2013

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Extracorporeal Membrane Oxygenation
Oxygenation
Hemolysis
Blood
Pumps
Membranes
L-Lactate Dehydrogenase
Hemoglobin
Lactic Acid
Hemoglobins
Plasmas
Costs and Cost Analysis
Body Surface Area
Costs
Oxidoreductases
Networks (circuits)
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

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title = "Comparison of hemolysis between centrimag and rotaflow rotary blood pumps during extracorporeal membrane oxygenation",
abstract = "The purpose of this investigation was to compare the hemolysis levels for patients on extracorporeal membrane oxygenation (ECMO) incorporating two different rotary blood pumps (CentriMag [CMAG] and RotaFlow [RF]) in identical circuits otherwise. The difference between the two pumps is the cost. One is 20-30 times less expensive than the other. A retrospective analysis of all patients placed on ECMO from June 2008 through May 2012 was done to evaluate hemolysis. Daily plasma hemoglobin (pHb), lactate dehydrogenase (LDH), and lactate levels were collected on all patients. Values were compared between those patients who received a CMAG and those who received an RF. Patients had to be on ECMO for more than 2 days to be included in the study. Linear mixed effects models were fit to the data to assess differences over time for each continuous outcome. Forty patients were placed on ECMO incorporating CMAG, whereas 40 patients received an RF. There were no significant statistical differences between CMAG and RF groups when comparing days on support (8.7±5.0; 8.4±5.7), age (44.8±18.3; 46.1±16.0), body surface area (2.03±0.36; 1.96±0.31), gender (male: 58{\%}, female: 42{\%}; male: 55{\%}, female: 45{\%}), etiology, type of support (veno-arterial [VA)]: 78{\%}, veno-venous [VV)]: 22{\%}; VA: 82{\%}, VV: 18{\%}) and pre-ECMO LDH levels (4004.0±3583.2; 3603.7±3354.1). There were also no significant differences between the CMAG and RF groups when comparing the mean values for daily pHb levels (5.7±3.6; 5.7±4.2), lactate levels (2.8±1.9; 3.0±2.1), and LDH levels (2656.3±1606.8; 2688.6±1726.1) or daily lactate, LDH, and pHb levels for the first 10 days of support. From our investigation, there is no difference between the CMAG and the RF blood pumps in regard to the creation of hemolysis during ECMO. The difference in cost of the devices does not correlate with the performance and outcomes.",
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Comparison of hemolysis between centrimag and rotaflow rotary blood pumps during extracorporeal membrane oxygenation. / Palanzo, David A.; El-Banayosy, Aly; Stephenson, Edward; Brehm, Christoph; Kunselman, Allen; Pae, Walter.

In: Artificial Organs, Vol. 37, No. 9, 01.09.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of hemolysis between centrimag and rotaflow rotary blood pumps during extracorporeal membrane oxygenation

AU - Palanzo, David A.

AU - El-Banayosy, Aly

AU - Stephenson, Edward

AU - Brehm, Christoph

AU - Kunselman, Allen

AU - Pae, Walter

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N2 - The purpose of this investigation was to compare the hemolysis levels for patients on extracorporeal membrane oxygenation (ECMO) incorporating two different rotary blood pumps (CentriMag [CMAG] and RotaFlow [RF]) in identical circuits otherwise. The difference between the two pumps is the cost. One is 20-30 times less expensive than the other. A retrospective analysis of all patients placed on ECMO from June 2008 through May 2012 was done to evaluate hemolysis. Daily plasma hemoglobin (pHb), lactate dehydrogenase (LDH), and lactate levels were collected on all patients. Values were compared between those patients who received a CMAG and those who received an RF. Patients had to be on ECMO for more than 2 days to be included in the study. Linear mixed effects models were fit to the data to assess differences over time for each continuous outcome. Forty patients were placed on ECMO incorporating CMAG, whereas 40 patients received an RF. There were no significant statistical differences between CMAG and RF groups when comparing days on support (8.7±5.0; 8.4±5.7), age (44.8±18.3; 46.1±16.0), body surface area (2.03±0.36; 1.96±0.31), gender (male: 58%, female: 42%; male: 55%, female: 45%), etiology, type of support (veno-arterial [VA)]: 78%, veno-venous [VV)]: 22%; VA: 82%, VV: 18%) and pre-ECMO LDH levels (4004.0±3583.2; 3603.7±3354.1). There were also no significant differences between the CMAG and RF groups when comparing the mean values for daily pHb levels (5.7±3.6; 5.7±4.2), lactate levels (2.8±1.9; 3.0±2.1), and LDH levels (2656.3±1606.8; 2688.6±1726.1) or daily lactate, LDH, and pHb levels for the first 10 days of support. From our investigation, there is no difference between the CMAG and the RF blood pumps in regard to the creation of hemolysis during ECMO. The difference in cost of the devices does not correlate with the performance and outcomes.

AB - The purpose of this investigation was to compare the hemolysis levels for patients on extracorporeal membrane oxygenation (ECMO) incorporating two different rotary blood pumps (CentriMag [CMAG] and RotaFlow [RF]) in identical circuits otherwise. The difference between the two pumps is the cost. One is 20-30 times less expensive than the other. A retrospective analysis of all patients placed on ECMO from June 2008 through May 2012 was done to evaluate hemolysis. Daily plasma hemoglobin (pHb), lactate dehydrogenase (LDH), and lactate levels were collected on all patients. Values were compared between those patients who received a CMAG and those who received an RF. Patients had to be on ECMO for more than 2 days to be included in the study. Linear mixed effects models were fit to the data to assess differences over time for each continuous outcome. Forty patients were placed on ECMO incorporating CMAG, whereas 40 patients received an RF. There were no significant statistical differences between CMAG and RF groups when comparing days on support (8.7±5.0; 8.4±5.7), age (44.8±18.3; 46.1±16.0), body surface area (2.03±0.36; 1.96±0.31), gender (male: 58%, female: 42%; male: 55%, female: 45%), etiology, type of support (veno-arterial [VA)]: 78%, veno-venous [VV)]: 22%; VA: 82%, VV: 18%) and pre-ECMO LDH levels (4004.0±3583.2; 3603.7±3354.1). There were also no significant differences between the CMAG and RF groups when comparing the mean values for daily pHb levels (5.7±3.6; 5.7±4.2), lactate levels (2.8±1.9; 3.0±2.1), and LDH levels (2656.3±1606.8; 2688.6±1726.1) or daily lactate, LDH, and pHb levels for the first 10 days of support. From our investigation, there is no difference between the CMAG and the RF blood pumps in regard to the creation of hemolysis during ECMO. The difference in cost of the devices does not correlate with the performance and outcomes.

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