Comparison of magnetic resonance imaging and laser doppler anemometry velocity measurements downstream of replacement heart valves: Implications for in vivo assessment of prosthetic valve function

Arnold Anthony Fontaine, Russell S. Heinrich, Peter G. Walker, Eric M. Pedersen, Markus B. Scheidegger, Peter Boesiger, Stephen P. Walton, Ajit P. Yoganathan

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Background and aim of the study: The non-invasive, in-vivo assessment of prosthetic valve function is compromised by the lack of accurate measurements of the transvalvular flow fields or hemodynamics by current techniques. Short echo time magnetic resonance imaging (MRI) may provide a method for the non-invasive, in vivo assessment of prosthetic valve function by accurately measuring changes in the transvalvular flow fields associated with normal and dysfunctional prosthetic valves. The objectives of these in vitro experiments were to investigate the potential for using MRI as a tool to measure the complex flow fields distal to replacement heart valves, and to assess the accuracy of MRI velocity measurements by comparison with Laser Doppler Anemometry (LDA), a gold standard. Methods: The velocity fields downstream of tilting disc, bileaflet, ball and cage, and pericardial tissue valves were measured using both three-component LDA and MRI phase velocity encoding under a steady flow rate of 22.81/min, simulating peak systolic flow. The valves were tested under normal and stenotic conditions to assess the MRI capabilities under a wide range of local flow conditions, velocities and turbulence levels. A new short echo time MRI technique (FAcE), which allowed velocity measurements in stenotic jets with high turbulence, was tested. Results: Good overall agreement was obtained between the MRI velocity measurements and the LDA data. The MRI velocity measurements adequately reproduced the spatial structure of the flow fields. In most cases peak velocities were accurately measured to within 15%. Conclusions: The results indicate that the FAcE MRI method has the potential to be used as a diagnostic tool to assess prosthetic valve function.

Original languageEnglish (US)
Pages (from-to)66-73
Number of pages8
JournalJournal of Heart Valve Disease
Volume5
Issue number1
StatePublished - Jan 1 1996

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Heart Valves
Lasers
Magnetic Resonance Imaging
Culture Diffusion Chambers
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Fontaine, Arnold Anthony ; Heinrich, Russell S. ; Walker, Peter G. ; Pedersen, Eric M. ; Scheidegger, Markus B. ; Boesiger, Peter ; Walton, Stephen P. ; Yoganathan, Ajit P. / Comparison of magnetic resonance imaging and laser doppler anemometry velocity measurements downstream of replacement heart valves : Implications for in vivo assessment of prosthetic valve function. In: Journal of Heart Valve Disease. 1996 ; Vol. 5, No. 1. pp. 66-73.
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abstract = "Background and aim of the study: The non-invasive, in-vivo assessment of prosthetic valve function is compromised by the lack of accurate measurements of the transvalvular flow fields or hemodynamics by current techniques. Short echo time magnetic resonance imaging (MRI) may provide a method for the non-invasive, in vivo assessment of prosthetic valve function by accurately measuring changes in the transvalvular flow fields associated with normal and dysfunctional prosthetic valves. The objectives of these in vitro experiments were to investigate the potential for using MRI as a tool to measure the complex flow fields distal to replacement heart valves, and to assess the accuracy of MRI velocity measurements by comparison with Laser Doppler Anemometry (LDA), a gold standard. Methods: The velocity fields downstream of tilting disc, bileaflet, ball and cage, and pericardial tissue valves were measured using both three-component LDA and MRI phase velocity encoding under a steady flow rate of 22.81/min, simulating peak systolic flow. The valves were tested under normal and stenotic conditions to assess the MRI capabilities under a wide range of local flow conditions, velocities and turbulence levels. A new short echo time MRI technique (FAcE), which allowed velocity measurements in stenotic jets with high turbulence, was tested. Results: Good overall agreement was obtained between the MRI velocity measurements and the LDA data. The MRI velocity measurements adequately reproduced the spatial structure of the flow fields. In most cases peak velocities were accurately measured to within 15{\%}. Conclusions: The results indicate that the FAcE MRI method has the potential to be used as a diagnostic tool to assess prosthetic valve function.",
author = "Fontaine, {Arnold Anthony} and Heinrich, {Russell S.} and Walker, {Peter G.} and Pedersen, {Eric M.} and Scheidegger, {Markus B.} and Peter Boesiger and Walton, {Stephen P.} and Yoganathan, {Ajit P.}",
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Comparison of magnetic resonance imaging and laser doppler anemometry velocity measurements downstream of replacement heart valves : Implications for in vivo assessment of prosthetic valve function. / Fontaine, Arnold Anthony; Heinrich, Russell S.; Walker, Peter G.; Pedersen, Eric M.; Scheidegger, Markus B.; Boesiger, Peter; Walton, Stephen P.; Yoganathan, Ajit P.

In: Journal of Heart Valve Disease, Vol. 5, No. 1, 01.01.1996, p. 66-73.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Comparison of magnetic resonance imaging and laser doppler anemometry velocity measurements downstream of replacement heart valves

T2 - Implications for in vivo assessment of prosthetic valve function

AU - Fontaine, Arnold Anthony

AU - Heinrich, Russell S.

AU - Walker, Peter G.

AU - Pedersen, Eric M.

AU - Scheidegger, Markus B.

AU - Boesiger, Peter

AU - Walton, Stephen P.

AU - Yoganathan, Ajit P.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Background and aim of the study: The non-invasive, in-vivo assessment of prosthetic valve function is compromised by the lack of accurate measurements of the transvalvular flow fields or hemodynamics by current techniques. Short echo time magnetic resonance imaging (MRI) may provide a method for the non-invasive, in vivo assessment of prosthetic valve function by accurately measuring changes in the transvalvular flow fields associated with normal and dysfunctional prosthetic valves. The objectives of these in vitro experiments were to investigate the potential for using MRI as a tool to measure the complex flow fields distal to replacement heart valves, and to assess the accuracy of MRI velocity measurements by comparison with Laser Doppler Anemometry (LDA), a gold standard. Methods: The velocity fields downstream of tilting disc, bileaflet, ball and cage, and pericardial tissue valves were measured using both three-component LDA and MRI phase velocity encoding under a steady flow rate of 22.81/min, simulating peak systolic flow. The valves were tested under normal and stenotic conditions to assess the MRI capabilities under a wide range of local flow conditions, velocities and turbulence levels. A new short echo time MRI technique (FAcE), which allowed velocity measurements in stenotic jets with high turbulence, was tested. Results: Good overall agreement was obtained between the MRI velocity measurements and the LDA data. The MRI velocity measurements adequately reproduced the spatial structure of the flow fields. In most cases peak velocities were accurately measured to within 15%. Conclusions: The results indicate that the FAcE MRI method has the potential to be used as a diagnostic tool to assess prosthetic valve function.

AB - Background and aim of the study: The non-invasive, in-vivo assessment of prosthetic valve function is compromised by the lack of accurate measurements of the transvalvular flow fields or hemodynamics by current techniques. Short echo time magnetic resonance imaging (MRI) may provide a method for the non-invasive, in vivo assessment of prosthetic valve function by accurately measuring changes in the transvalvular flow fields associated with normal and dysfunctional prosthetic valves. The objectives of these in vitro experiments were to investigate the potential for using MRI as a tool to measure the complex flow fields distal to replacement heart valves, and to assess the accuracy of MRI velocity measurements by comparison with Laser Doppler Anemometry (LDA), a gold standard. Methods: The velocity fields downstream of tilting disc, bileaflet, ball and cage, and pericardial tissue valves were measured using both three-component LDA and MRI phase velocity encoding under a steady flow rate of 22.81/min, simulating peak systolic flow. The valves were tested under normal and stenotic conditions to assess the MRI capabilities under a wide range of local flow conditions, velocities and turbulence levels. A new short echo time MRI technique (FAcE), which allowed velocity measurements in stenotic jets with high turbulence, was tested. Results: Good overall agreement was obtained between the MRI velocity measurements and the LDA data. The MRI velocity measurements adequately reproduced the spatial structure of the flow fields. In most cases peak velocities were accurately measured to within 15%. Conclusions: The results indicate that the FAcE MRI method has the potential to be used as a diagnostic tool to assess prosthetic valve function.

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