Comparison of Physiologic and Pharmacologic Assessment of Growth Hormone Secretion

Selma F. Siegel, Dorothy J. Becker, Peter Lee, James P. Gutai, Thomas P. Foley, Allan L. Drash

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

To determine if pharmacologic and physiologic tests are equally effective in the assessment of growth hormone secretory status, serum GH levels were measured during sequential tests with intravenous arginine infusion and insulin-induced hypoglycemia and during sleep in 62 children, aged 2.1 to 17.3 years. Responses during AITT and sleep were concordant in 53 patients and discordant in nine patients. Arginine-insulin tolerance test results were consistent with the subsequent clinical course in 80% of the patients while nocturnal sampling was consistent with the subsequent clinical course in 93% of the patients. Thus, the failure of a normal serum GH response to pharmacologic stimuli is not always a diagnostic indicator of GH deficiency. Additional investigation of discordant GH responses to pharmacologic and physiologic stimuli may lead to a further understanding of the control mechanisms of GH secretion.

Original languageEnglish (US)
Pages (from-to)540-543
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume138
Issue number6
DOIs
StatePublished - Jun 1984

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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