Comparison of Physiologic and Pharmacologic Assessment of Growth Hormone Secretion

Selma F. Siegel, Dorothy J. Becker, Peter Lee, James P. Gutai, Thomas P. Foley, Allan L. Drash

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To determine if pharmacologic and physiologic tests are equally effective in the assessment of growth hormone secretory status, serum GH levels were measured during sequential tests with intravenous arginine infusion and insulin-induced hypoglycemia and during sleep in 62 children, aged 2.1 to 17.3 years. Responses during AITT and sleep were concordant in 53 patients and discordant in nine patients. Arginine-insulin tolerance test results were consistent with the subsequent clinical course in 80% of the patients while nocturnal sampling was consistent with the subsequent clinical course in 93% of the patients. Thus, the failure of a normal serum GH response to pharmacologic stimuli is not always a diagnostic indicator of GH deficiency. Additional investigation of discordant GH responses to pharmacologic and physiologic stimuli may lead to a further understanding of the control mechanisms of GH secretion.

Original languageEnglish (US)
Pages (from-to)540-543
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume138
Issue number6
DOIs
StatePublished - Jan 1 1984

Fingerprint

Growth Hormone
Arginine
Sleep
Insulin
Serum
Hypoglycemia
Intravenous Infusions

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Siegel, Selma F. ; Becker, Dorothy J. ; Lee, Peter ; Gutai, James P. ; Foley, Thomas P. ; Drash, Allan L. / Comparison of Physiologic and Pharmacologic Assessment of Growth Hormone Secretion. In: American Journal of Diseases of Children. 1984 ; Vol. 138, No. 6. pp. 540-543.
@article{967982a6e6e940c09a5b065d30ddd527,
title = "Comparison of Physiologic and Pharmacologic Assessment of Growth Hormone Secretion",
abstract = "To determine if pharmacologic and physiologic tests are equally effective in the assessment of growth hormone secretory status, serum GH levels were measured during sequential tests with intravenous arginine infusion and insulin-induced hypoglycemia and during sleep in 62 children, aged 2.1 to 17.3 years. Responses during AITT and sleep were concordant in 53 patients and discordant in nine patients. Arginine-insulin tolerance test results were consistent with the subsequent clinical course in 80{\%} of the patients while nocturnal sampling was consistent with the subsequent clinical course in 93{\%} of the patients. Thus, the failure of a normal serum GH response to pharmacologic stimuli is not always a diagnostic indicator of GH deficiency. Additional investigation of discordant GH responses to pharmacologic and physiologic stimuli may lead to a further understanding of the control mechanisms of GH secretion.",
author = "Siegel, {Selma F.} and Becker, {Dorothy J.} and Peter Lee and Gutai, {James P.} and Foley, {Thomas P.} and Drash, {Allan L.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1001/archpedi.1984.02140440024005",
language = "English (US)",
volume = "138",
pages = "540--543",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "6",

}

Comparison of Physiologic and Pharmacologic Assessment of Growth Hormone Secretion. / Siegel, Selma F.; Becker, Dorothy J.; Lee, Peter; Gutai, James P.; Foley, Thomas P.; Drash, Allan L.

In: American Journal of Diseases of Children, Vol. 138, No. 6, 01.01.1984, p. 540-543.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of Physiologic and Pharmacologic Assessment of Growth Hormone Secretion

AU - Siegel, Selma F.

AU - Becker, Dorothy J.

AU - Lee, Peter

AU - Gutai, James P.

AU - Foley, Thomas P.

AU - Drash, Allan L.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - To determine if pharmacologic and physiologic tests are equally effective in the assessment of growth hormone secretory status, serum GH levels were measured during sequential tests with intravenous arginine infusion and insulin-induced hypoglycemia and during sleep in 62 children, aged 2.1 to 17.3 years. Responses during AITT and sleep were concordant in 53 patients and discordant in nine patients. Arginine-insulin tolerance test results were consistent with the subsequent clinical course in 80% of the patients while nocturnal sampling was consistent with the subsequent clinical course in 93% of the patients. Thus, the failure of a normal serum GH response to pharmacologic stimuli is not always a diagnostic indicator of GH deficiency. Additional investigation of discordant GH responses to pharmacologic and physiologic stimuli may lead to a further understanding of the control mechanisms of GH secretion.

AB - To determine if pharmacologic and physiologic tests are equally effective in the assessment of growth hormone secretory status, serum GH levels were measured during sequential tests with intravenous arginine infusion and insulin-induced hypoglycemia and during sleep in 62 children, aged 2.1 to 17.3 years. Responses during AITT and sleep were concordant in 53 patients and discordant in nine patients. Arginine-insulin tolerance test results were consistent with the subsequent clinical course in 80% of the patients while nocturnal sampling was consistent with the subsequent clinical course in 93% of the patients. Thus, the failure of a normal serum GH response to pharmacologic stimuli is not always a diagnostic indicator of GH deficiency. Additional investigation of discordant GH responses to pharmacologic and physiologic stimuli may lead to a further understanding of the control mechanisms of GH secretion.

UR - http://www.scopus.com/inward/record.url?scp=0021240132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021240132&partnerID=8YFLogxK

U2 - 10.1001/archpedi.1984.02140440024005

DO - 10.1001/archpedi.1984.02140440024005

M3 - Article

C2 - 6372438

AN - SCOPUS:0021240132

VL - 138

SP - 540

EP - 543

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 6

ER -