This work performs a direct comparison between non-intrusive generalized polynomial chaos (GPC) expansion techniques applied to structural acoustic problems. Broadly, the GPC techniques are grouped in two categories: quadrature, where the stochastic sampling is predetermined according to a quadrature rule; and regression, where point selection schemes are devised to generate a representative sample of the random input. As a baseline comparison, Monte Carlo type simulations are also performed although they take many more sampling points. The test problems considered include both canonical and more applied cases that exemplify the features and types of calculations commonly arising in vibrations and acoustics. A range of different numbers of random input variables are considered. The primary point of comparison between the methods is the number of sampling points they require to generate an accurate GPC expansion. This is due to the general consideration that the most expensive part of a GPC analysis is evaluating the deterministic problem of interest; thus the method with the fewest sampling points will often be the fastest. Accuracy of each GPC expansion is judged using several metrics including basic statistical moments as well as features of the actual reconstructed probability density function.