Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group

M. Haring Sweeney, M. A. Fingerhut, D. G. Patterson, L. B. Connally, L. A. Piacitelli, J. A. Morris, A. L. Greife, R. W. Hornung, D. A. Marlow, J. E. Dugle, W. E. Halperin, L. L. Needham

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).

Original languageEnglish (US)
Pages (from-to)993-1000
Number of pages8
JournalChemosphere
Volume20
Issue number7-9
DOIs
StatePublished - 1990

Fingerprint

TCDD
Isomers
serum
Serum
half life
Half-Life
comparison
Polychlorinated Dibenzodioxins
exposure

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Sweeney, M. H., Fingerhut, M. A., Patterson, D. G., Connally, L. B., Piacitelli, L. A., Morris, J. A., ... Needham, L. L. (1990). Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group. Chemosphere, 20(7-9), 993-1000. https://doi.org/10.1016/0045-6535(90)90211-B
Sweeney, M. Haring ; Fingerhut, M. A. ; Patterson, D. G. ; Connally, L. B. ; Piacitelli, L. A. ; Morris, J. A. ; Greife, A. L. ; Hornung, R. W. ; Marlow, D. A. ; Dugle, J. E. ; Halperin, W. E. ; Needham, L. L. / Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group. In: Chemosphere. 1990 ; Vol. 20, No. 7-9. pp. 993-1000.
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abstract = "Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).",
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Sweeney, MH, Fingerhut, MA, Patterson, DG, Connally, LB, Piacitelli, LA, Morris, JA, Greife, AL, Hornung, RW, Marlow, DA, Dugle, JE, Halperin, WE & Needham, LL 1990, 'Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group', Chemosphere, vol. 20, no. 7-9, pp. 993-1000. https://doi.org/10.1016/0045-6535(90)90211-B

Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group. / Sweeney, M. Haring; Fingerhut, M. A.; Patterson, D. G.; Connally, L. B.; Piacitelli, L. A.; Morris, J. A.; Greife, A. L.; Hornung, R. W.; Marlow, D. A.; Dugle, J. E.; Halperin, W. E.; Needham, L. L.

In: Chemosphere, Vol. 20, No. 7-9, 1990, p. 993-1000.

Research output: Contribution to journalArticle

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T1 - Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group

AU - Sweeney, M. Haring

AU - Fingerhut, M. A.

AU - Patterson, D. G.

AU - Connally, L. B.

AU - Piacitelli, L. A.

AU - Morris, J. A.

AU - Greife, A. L.

AU - Hornung, R. W.

AU - Marlow, D. A.

AU - Dugle, J. E.

AU - Halperin, W. E.

AU - Needham, L. L.

PY - 1990

Y1 - 1990

N2 - Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).

AB - Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).

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Sweeney MH, Fingerhut MA, Patterson DG, Connally LB, Piacitelli LA, Morris JA et al. Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group. Chemosphere. 1990;20(7-9):993-1000. https://doi.org/10.1016/0045-6535(90)90211-B