Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group

M. Haring Sweeney, M. A. Fingerhut, D. G. Patterson, L. B. Connally, L. A. Piacitelli, J. A. Morris, A. L. Greife, R. W. Hornung, D. A. Marlow, J. E. Dugle, W. E. Halperin, L. L. Needham

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Abstract

Serum 2,3,7,8-TCDD levels were measured as an estimate of exposure to this isomer in 143 workers who were employed at either of two plants in New Jersey and Missouri which manufactured chemicals contaminated with 2,3,7,8-TCDD and in 54 unexposed referents. The mean serum 2,3,7,8-TCDD levels for all workers was 251.7 parts per trillion (ppt) and, for all referents combined, the mean serum level was 7.8 ppt. The mean level of 2,3,7,8-TCDD present in the serum of workers at the date of termination of exposure (half-life extrapolated) was 2600 ppt and 870 ppt for the New Jersey and Missouri workers, respectively. Overall, the levels in the workers significantly correlated with duration of exposure in 2,3,7,8-TCDD-contaminated processes (r = 0.83, p< .0001).

Original languageEnglish (US)
Pages (from-to)993-1000
Number of pages8
JournalChemosphere
Volume20
Issue number7-9
DOIs
Publication statusPublished - 1990

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All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Sweeney, M. H., Fingerhut, M. A., Patterson, D. G., Connally, L. B., Piacitelli, L. A., Morris, J. A., ... Needham, L. L. (1990). Comparison of serum levels of 2,3,7,8-TCDD in TCP production workers and in an unexposed comparison group. Chemosphere, 20(7-9), 993-1000. https://doi.org/10.1016/0045-6535(90)90211-B