Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury

Robinder G. Khemani, Neal J. Thomas, Vani Venkatachalam, Jason P. Scimeme, Ty Berutti, James B. Schneider, Patrick A. Ross, Douglas F. Willson, Mark W. Hall, Christopher J L Newth

Research output: Contribution to journalReview article

77 Citations (Scopus)

Abstract

Objective: Given pulse oximetry is increasingly substituting for arterial blood gas monitoring, noninvasive surrogate markers for lung disease severity are needed to stratify pediatric risk. We sought to validate prospectively the comparability of SpO 2/FiO 2 to PaO 2/FiO 2 and oxygen saturation index to oxygenation index in children. We also sought to derive a noninvasive lung injury score. Design: Prospective, multicentered observational study in six pediatric intensive care units. Patients: One hundred thirty-seven mechanically ventilated children with SpO 2 80% to 97% and an indwelling arterial catheter. Interventions: Simultaneous blood gas, pulse oximetry, and ventilator settings were collected. Derivation and validation data sets were generated, and linear mixed modeling was used to derive predictive equations. Model performance and fit were evaluated using the validation data set. Measurements and Main Results: One thousand one hundred ninety blood gas, SpO 2, and ventilator settings from 137 patients were included. Oxygen saturation index had a strong linear association with oxygenation index in both derivation and validation data sets, given by the equation oxygen saturation index = 2.76 1 0.547*oxygenation index (derivation). 1/SpO 2/FiO 2 had a strong linear association with 1/PaO 2/FiO 2 in both derivation and validation data sets given by the equation 1/SpO 2/FiO 2 = 0.00232 1 0.443/PaO 2/FiO 2 (derivation). SpO 2/FiO 2 criteria for acute respiratory distress syndrome and acute lung injury were 221 (95% confidence interval 215-226) and 264 (95% confidence interval 259-269). Multivariate models demonstrated that oxygenation index, serum pH, and PacO 2 were associated with oxygen saturation index (p < .05); and 1/PaO 2/FiO 2, mean airway pressure, serum pH, and PacO 2 were associated with 1/SpO 2/FiO 2 (p < .05). There was strong concordance between the derived noninvasive lung injury score and the original pediatric modification of lung injury score with a mean difference of 20.0361 α0.264 sd. Conclusions: Lung injury severity markers, which use SpO 2, are adequate surrogate markers for those that use PaO 2 in children with respiratory failure for SpO 2 between 80% and 97%. They should be used in clinical practice to characterize risk, to increase enrollment in clinical trials, and to determine disease prevalence.

Original languageEnglish (US)
Pages (from-to)1309-1316
Number of pages8
JournalCritical care medicine
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2012

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Acute Lung Injury
Lung Injury
Lung Diseases
Oxygen
Oximetry
Gases
Mechanical Ventilators
Biomarkers
Confidence Intervals
Pediatrics
Pediatric Intensive Care Units
Indwelling Catheters
Adult Respiratory Distress Syndrome
Serum
Respiratory Insufficiency
Observational Studies
Clinical Trials
Pressure
Datasets

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Khemani, R. G., Thomas, N. J., Venkatachalam, V., Scimeme, J. P., Berutti, T., Schneider, J. B., ... Newth, C. J. L. (2012). Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury. Critical care medicine, 40(4), 1309-1316. https://doi.org/10.1097/CCM.0b013e31823bc61b
Khemani, Robinder G. ; Thomas, Neal J. ; Venkatachalam, Vani ; Scimeme, Jason P. ; Berutti, Ty ; Schneider, James B. ; Ross, Patrick A. ; Willson, Douglas F. ; Hall, Mark W. ; Newth, Christopher J L. / Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury. In: Critical care medicine. 2012 ; Vol. 40, No. 4. pp. 1309-1316.
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title = "Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury",
abstract = "Objective: Given pulse oximetry is increasingly substituting for arterial blood gas monitoring, noninvasive surrogate markers for lung disease severity are needed to stratify pediatric risk. We sought to validate prospectively the comparability of SpO 2/FiO 2 to PaO 2/FiO 2 and oxygen saturation index to oxygenation index in children. We also sought to derive a noninvasive lung injury score. Design: Prospective, multicentered observational study in six pediatric intensive care units. Patients: One hundred thirty-seven mechanically ventilated children with SpO 2 80{\%} to 97{\%} and an indwelling arterial catheter. Interventions: Simultaneous blood gas, pulse oximetry, and ventilator settings were collected. Derivation and validation data sets were generated, and linear mixed modeling was used to derive predictive equations. Model performance and fit were evaluated using the validation data set. Measurements and Main Results: One thousand one hundred ninety blood gas, SpO 2, and ventilator settings from 137 patients were included. Oxygen saturation index had a strong linear association with oxygenation index in both derivation and validation data sets, given by the equation oxygen saturation index = 2.76 1 0.547*oxygenation index (derivation). 1/SpO 2/FiO 2 had a strong linear association with 1/PaO 2/FiO 2 in both derivation and validation data sets given by the equation 1/SpO 2/FiO 2 = 0.00232 1 0.443/PaO 2/FiO 2 (derivation). SpO 2/FiO 2 criteria for acute respiratory distress syndrome and acute lung injury were 221 (95{\%} confidence interval 215-226) and 264 (95{\%} confidence interval 259-269). Multivariate models demonstrated that oxygenation index, serum pH, and PacO 2 were associated with oxygen saturation index (p < .05); and 1/PaO 2/FiO 2, mean airway pressure, serum pH, and PacO 2 were associated with 1/SpO 2/FiO 2 (p < .05). There was strong concordance between the derived noninvasive lung injury score and the original pediatric modification of lung injury score with a mean difference of 20.0361 α0.264 sd. Conclusions: Lung injury severity markers, which use SpO 2, are adequate surrogate markers for those that use PaO 2 in children with respiratory failure for SpO 2 between 80{\%} and 97{\%}. They should be used in clinical practice to characterize risk, to increase enrollment in clinical trials, and to determine disease prevalence.",
author = "Khemani, {Robinder G.} and Thomas, {Neal J.} and Vani Venkatachalam and Scimeme, {Jason P.} and Ty Berutti and Schneider, {James B.} and Ross, {Patrick A.} and Willson, {Douglas F.} and Hall, {Mark W.} and Newth, {Christopher J L}",
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Khemani, RG, Thomas, NJ, Venkatachalam, V, Scimeme, JP, Berutti, T, Schneider, JB, Ross, PA, Willson, DF, Hall, MW & Newth, CJL 2012, 'Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury', Critical care medicine, vol. 40, no. 4, pp. 1309-1316. https://doi.org/10.1097/CCM.0b013e31823bc61b

Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury. / Khemani, Robinder G.; Thomas, Neal J.; Venkatachalam, Vani; Scimeme, Jason P.; Berutti, Ty; Schneider, James B.; Ross, Patrick A.; Willson, Douglas F.; Hall, Mark W.; Newth, Christopher J L.

In: Critical care medicine, Vol. 40, No. 4, 01.04.2012, p. 1309-1316.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Comparison of SpO 2 to PaO 2 based markers of lung disease severity for children with acute lung injury

AU - Khemani, Robinder G.

AU - Thomas, Neal J.

AU - Venkatachalam, Vani

AU - Scimeme, Jason P.

AU - Berutti, Ty

AU - Schneider, James B.

AU - Ross, Patrick A.

AU - Willson, Douglas F.

AU - Hall, Mark W.

AU - Newth, Christopher J L

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: Given pulse oximetry is increasingly substituting for arterial blood gas monitoring, noninvasive surrogate markers for lung disease severity are needed to stratify pediatric risk. We sought to validate prospectively the comparability of SpO 2/FiO 2 to PaO 2/FiO 2 and oxygen saturation index to oxygenation index in children. We also sought to derive a noninvasive lung injury score. Design: Prospective, multicentered observational study in six pediatric intensive care units. Patients: One hundred thirty-seven mechanically ventilated children with SpO 2 80% to 97% and an indwelling arterial catheter. Interventions: Simultaneous blood gas, pulse oximetry, and ventilator settings were collected. Derivation and validation data sets were generated, and linear mixed modeling was used to derive predictive equations. Model performance and fit were evaluated using the validation data set. Measurements and Main Results: One thousand one hundred ninety blood gas, SpO 2, and ventilator settings from 137 patients were included. Oxygen saturation index had a strong linear association with oxygenation index in both derivation and validation data sets, given by the equation oxygen saturation index = 2.76 1 0.547*oxygenation index (derivation). 1/SpO 2/FiO 2 had a strong linear association with 1/PaO 2/FiO 2 in both derivation and validation data sets given by the equation 1/SpO 2/FiO 2 = 0.00232 1 0.443/PaO 2/FiO 2 (derivation). SpO 2/FiO 2 criteria for acute respiratory distress syndrome and acute lung injury were 221 (95% confidence interval 215-226) and 264 (95% confidence interval 259-269). Multivariate models demonstrated that oxygenation index, serum pH, and PacO 2 were associated with oxygen saturation index (p < .05); and 1/PaO 2/FiO 2, mean airway pressure, serum pH, and PacO 2 were associated with 1/SpO 2/FiO 2 (p < .05). There was strong concordance between the derived noninvasive lung injury score and the original pediatric modification of lung injury score with a mean difference of 20.0361 α0.264 sd. Conclusions: Lung injury severity markers, which use SpO 2, are adequate surrogate markers for those that use PaO 2 in children with respiratory failure for SpO 2 between 80% and 97%. They should be used in clinical practice to characterize risk, to increase enrollment in clinical trials, and to determine disease prevalence.

AB - Objective: Given pulse oximetry is increasingly substituting for arterial blood gas monitoring, noninvasive surrogate markers for lung disease severity are needed to stratify pediatric risk. We sought to validate prospectively the comparability of SpO 2/FiO 2 to PaO 2/FiO 2 and oxygen saturation index to oxygenation index in children. We also sought to derive a noninvasive lung injury score. Design: Prospective, multicentered observational study in six pediatric intensive care units. Patients: One hundred thirty-seven mechanically ventilated children with SpO 2 80% to 97% and an indwelling arterial catheter. Interventions: Simultaneous blood gas, pulse oximetry, and ventilator settings were collected. Derivation and validation data sets were generated, and linear mixed modeling was used to derive predictive equations. Model performance and fit were evaluated using the validation data set. Measurements and Main Results: One thousand one hundred ninety blood gas, SpO 2, and ventilator settings from 137 patients were included. Oxygen saturation index had a strong linear association with oxygenation index in both derivation and validation data sets, given by the equation oxygen saturation index = 2.76 1 0.547*oxygenation index (derivation). 1/SpO 2/FiO 2 had a strong linear association with 1/PaO 2/FiO 2 in both derivation and validation data sets given by the equation 1/SpO 2/FiO 2 = 0.00232 1 0.443/PaO 2/FiO 2 (derivation). SpO 2/FiO 2 criteria for acute respiratory distress syndrome and acute lung injury were 221 (95% confidence interval 215-226) and 264 (95% confidence interval 259-269). Multivariate models demonstrated that oxygenation index, serum pH, and PacO 2 were associated with oxygen saturation index (p < .05); and 1/PaO 2/FiO 2, mean airway pressure, serum pH, and PacO 2 were associated with 1/SpO 2/FiO 2 (p < .05). There was strong concordance between the derived noninvasive lung injury score and the original pediatric modification of lung injury score with a mean difference of 20.0361 α0.264 sd. Conclusions: Lung injury severity markers, which use SpO 2, are adequate surrogate markers for those that use PaO 2 in children with respiratory failure for SpO 2 between 80% and 97%. They should be used in clinical practice to characterize risk, to increase enrollment in clinical trials, and to determine disease prevalence.

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