Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer

Nancy D. Turner, Jairam Vanamala, Tety Leonardi, Bhimanagouda S. Patil, Mary E. Murphy, Yingxue C. Liu, Naisyin Wang, Leonard M. Pike, Robert S. Chapkin, Joanne R. Lupton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Grapefruit, and isolated bioactive citrus compounds, are suggested to protect against some cancers. The ability of grapefruit pulp powder (irradiated or non-irradiated) and isolated compounds (apigenin, hesperidin, limonin, naringin, naringenin, nobiletin) to protect against colon cancer development were compared in Sprague Dawley rats. Rats were injected with saline or a colon carcinogen (azoxymethane, AOM, 15 mg/kg body weight, 2x, weeks 3 and 4) after starting the diets. All test diets, except hesperidin and nobiletin, reduced (P < 0.04) preneoplastic lesions (aberrant crypt foci, ACF) and increased (P < 0.05) apoptosis. Hesperidin, nobiletin and apigenin were the only diets that did not decrease (P < 0.04) proliferation of colonocytes. Untreated grapefruit pulp powder, limonin and naringenin prevented (P < 0.05) proliferative zone expansion in AOM-injected rats. The data indicate untreated grapefruit pulp powder, and certain isolated compounds, reduce ACF formation through changes in colonocyte proliferation and apoptosis. Because irradiated grapefruit pulp powder was not as effective as untreated grapefruit pulp powder in controlling proliferative zone expansion, it may not be as effective as untreated grapefruit pulp powder in colon cancer prevention.

Original languageEnglish (US)
Title of host publicationPotential Health Benefits of Citrus
PublisherAmerican Chemical Society
Pages121-129
Number of pages9
ISBN (Print)0841239576, 9780841239579
DOIs
StatePublished - 2006

Publication series

NameACS Symposium Series
Volume936
ISSN (Print)0097-6156

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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