Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer

Nancy D. Turner, Jairam Vanamala, Tety Leonardi, Bhimanagouda S. Patil, Mary E. Murphy, Yingxue C. Liu, Naisyin Wang, Leonard M. Pike, Robert S. Chapkin, Joanne R. Lupton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Grapefruit, and isolated bioactive citrus compounds, are suggested to protect against some cancers. The ability of grapefruit pulp powder (irradiated or non-irradiated) and isolated compounds (apigenin, hesperidin, limonin, naringin, naringenin, nobiletin) to protect against colon cancer development were compared in Sprague Dawley rats. Rats were injected with saline or a colon carcinogen (azoxymethane, AOM, 15 mg/kg body weight, 2x, weeks 3 and 4) after starting the diets. All test diets, except hesperidin and nobiletin, reduced (P < 0.04) preneoplastic lesions (aberrant crypt foci, ACF) and increased (P < 0.05) apoptosis. Hesperidin, nobiletin and apigenin were the only diets that did not decrease (P < 0.04) proliferation of colonocytes. Untreated grapefruit pulp powder, limonin and naringenin prevented (P < 0.05) proliferative zone expansion in AOM-injected rats. The data indicate untreated grapefruit pulp powder, and certain isolated compounds, reduce ACF formation through changes in colonocyte proliferation and apoptosis. Because irradiated grapefruit pulp powder was not as effective as untreated grapefruit pulp powder in controlling proliferative zone expansion, it may not be as effective as untreated grapefruit pulp powder in colon cancer prevention.

Original languageEnglish (US)
Title of host publicationPotential Health Benefits of Citrus
EditorsBhimanagouda Patil, Nancy Turner, Edward Miller, Jennifer Brodbelt
Pages121-129
Number of pages9
StatePublished - Dec 1 2006

Publication series

NameACS Symposium Series
Volume936
ISSN (Print)0097-6156

Fingerprint

Powders
Pulp
Hesperidin
Nutrition
Apigenin
Rats
Cell death
Azoxymethane
Apoptosis
Carcinogens
nobiletin
limonin
naringenin

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Turner, N. D., Vanamala, J., Leonardi, T., Patil, B. S., Murphy, M. E., Liu, Y. C., ... Lupton, J. R. (2006). Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer. In B. Patil, N. Turner, E. Miller, & J. Brodbelt (Eds.), Potential Health Benefits of Citrus (pp. 121-129). (ACS Symposium Series; Vol. 936).
Turner, Nancy D. ; Vanamala, Jairam ; Leonardi, Tety ; Patil, Bhimanagouda S. ; Murphy, Mary E. ; Liu, Yingxue C. ; Wang, Naisyin ; Pike, Leonard M. ; Chapkin, Robert S. ; Lupton, Joanne R. / Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer. Potential Health Benefits of Citrus. editor / Bhimanagouda Patil ; Nancy Turner ; Edward Miller ; Jennifer Brodbelt. 2006. pp. 121-129 (ACS Symposium Series).
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Turner, ND, Vanamala, J, Leonardi, T, Patil, BS, Murphy, ME, Liu, YC, Wang, N, Pike, LM, Chapkin, RS & Lupton, JR 2006, Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer. in B Patil, N Turner, E Miller & J Brodbelt (eds), Potential Health Benefits of Citrus. ACS Symposium Series, vol. 936, pp. 121-129.

Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer. / Turner, Nancy D.; Vanamala, Jairam; Leonardi, Tety; Patil, Bhimanagouda S.; Murphy, Mary E.; Liu, Yingxue C.; Wang, Naisyin; Pike, Leonard M.; Chapkin, Robert S.; Lupton, Joanne R.

Potential Health Benefits of Citrus. ed. / Bhimanagouda Patil; Nancy Turner; Edward Miller; Jennifer Brodbelt. 2006. p. 121-129 (ACS Symposium Series; Vol. 936).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Turner ND, Vanamala J, Leonardi T, Patil BS, Murphy ME, Liu YC et al. Comparison of the chemoprotection conferred by grapefruit and isolated bioactive compounds against colon cancer. In Patil B, Turner N, Miller E, Brodbelt J, editors, Potential Health Benefits of Citrus. 2006. p. 121-129. (ACS Symposium Series).