Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

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The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG

Original languageEnglish (US)
Pages (from-to)1353-1361
Number of pages9
JournalNucleic acids research
Issue number4
StatePublished - Feb 25 1987


All Science Journal Classification (ASJC) codes

  • Genetics

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