Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

Research output: Contribution to journalArticle

710 Citations (Scopus)

Abstract

The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG

Original languageEnglish (US)
Pages (from-to)1353-1361
Number of pages9
JournalNucleic acids research
Volume15
Issue number4
DOIs
StatePublished - Feb 25 1987

Fingerprint

Consensus Sequence
Drosophilidae
Drosophila
Vertebrates
Genes
Messenger RNA
Assignment
Restriction
Gene

All Science Journal Classification (ASJC) codes

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this

@article{e5c2f62e0e07435b82730047435df88d,
title = "Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates",
abstract = "The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG",
author = "Cavener, {Douglas R.}",
year = "1987",
month = "2",
day = "25",
doi = "10.1093/nar/15.4.1353",
language = "English (US)",
volume = "15",
pages = "1353--1361",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "4",

}

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. / Cavener, Douglas R.

In: Nucleic acids research, Vol. 15, No. 4, 25.02.1987, p. 1353-1361.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

AU - Cavener, Douglas R.

PY - 1987/2/25

Y1 - 1987/2/25

N2 - The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG

AB - The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak (1) was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CANCAUG

UR - http://www.scopus.com/inward/record.url?scp=0023664018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023664018&partnerID=8YFLogxK

U2 - 10.1093/nar/15.4.1353

DO - 10.1093/nar/15.4.1353

M3 - Article

VL - 15

SP - 1353

EP - 1361

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 4

ER -