Comparison of the effects of mezlocillin, carbenicillin, and placebo on normal hemostasis

J. O. Ballard, S. G. Barnes, F. R. Sattler

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mezlocillin was compared with carbenicillin and 0.9% NaCl as placebo in a double-blind manner to determine its effect in vivo on hemostasis in normal volunteers. Eighteen subjects were randomized to receive mezlocillin, 4 g every 6 h; carbenicillin, 7.5 g every 6 h; or placebo, 50 ml every 6 h, each given for 20 intravenous doses unless the template bleeding time after 10 doses was >15 min. Template bleeding times were determined before the dose 1 and 1 h after doses 10 and 20. Five of six (83%) subjects receiving carbenicillin developed template bleeding time prolongation to >21 min, and two of six (33%) subjects receiving mezlocillin and one of six (17%) subjects receiving carbenicillin had mild template bleeding time prolongations of <13 min. Coagulation studies (prothrombin time, partial thromboplastin time, and thrombin time) were normal in all subjects, and blood salicylate levels were negative. Thus, in standard therapeutic doses, mezlocillin was less likely than carbenicillin to prolong the template bleeding time above normal (P = 0.04) and, when prolongation occurred with mezlocillin, it was mild. These data support the selective use of mezlocillin in patients at increased risk for bleeding and who require therapy with an antipseudomonal penicillin.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume25
Issue number2
DOIs
StatePublished - Jan 1 1984

Fingerprint

Mezlocillin
Carbenicillin
Hemostasis
Bleeding Time
Placebos
Thrombin Time
Partial Thromboplastin Time
Salicylates
Penicillins
Healthy Volunteers
Hemorrhage
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Ballard, J. O. ; Barnes, S. G. ; Sattler, F. R. / Comparison of the effects of mezlocillin, carbenicillin, and placebo on normal hemostasis. In: Antimicrobial agents and chemotherapy. 1984 ; Vol. 25, No. 2. pp. 153-156.
@article{d19e1b48bde2448c8ece46934e919048,
title = "Comparison of the effects of mezlocillin, carbenicillin, and placebo on normal hemostasis",
abstract = "Mezlocillin was compared with carbenicillin and 0.9{\%} NaCl as placebo in a double-blind manner to determine its effect in vivo on hemostasis in normal volunteers. Eighteen subjects were randomized to receive mezlocillin, 4 g every 6 h; carbenicillin, 7.5 g every 6 h; or placebo, 50 ml every 6 h, each given for 20 intravenous doses unless the template bleeding time after 10 doses was >15 min. Template bleeding times were determined before the dose 1 and 1 h after doses 10 and 20. Five of six (83{\%}) subjects receiving carbenicillin developed template bleeding time prolongation to >21 min, and two of six (33{\%}) subjects receiving mezlocillin and one of six (17{\%}) subjects receiving carbenicillin had mild template bleeding time prolongations of <13 min. Coagulation studies (prothrombin time, partial thromboplastin time, and thrombin time) were normal in all subjects, and blood salicylate levels were negative. Thus, in standard therapeutic doses, mezlocillin was less likely than carbenicillin to prolong the template bleeding time above normal (P = 0.04) and, when prolongation occurred with mezlocillin, it was mild. These data support the selective use of mezlocillin in patients at increased risk for bleeding and who require therapy with an antipseudomonal penicillin.",
author = "Ballard, {J. O.} and Barnes, {S. G.} and Sattler, {F. R.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1128/AAC.25.2.153",
language = "English (US)",
volume = "25",
pages = "153--156",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "2",

}

Comparison of the effects of mezlocillin, carbenicillin, and placebo on normal hemostasis. / Ballard, J. O.; Barnes, S. G.; Sattler, F. R.

In: Antimicrobial agents and chemotherapy, Vol. 25, No. 2, 01.01.1984, p. 153-156.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of the effects of mezlocillin, carbenicillin, and placebo on normal hemostasis

AU - Ballard, J. O.

AU - Barnes, S. G.

AU - Sattler, F. R.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Mezlocillin was compared with carbenicillin and 0.9% NaCl as placebo in a double-blind manner to determine its effect in vivo on hemostasis in normal volunteers. Eighteen subjects were randomized to receive mezlocillin, 4 g every 6 h; carbenicillin, 7.5 g every 6 h; or placebo, 50 ml every 6 h, each given for 20 intravenous doses unless the template bleeding time after 10 doses was >15 min. Template bleeding times were determined before the dose 1 and 1 h after doses 10 and 20. Five of six (83%) subjects receiving carbenicillin developed template bleeding time prolongation to >21 min, and two of six (33%) subjects receiving mezlocillin and one of six (17%) subjects receiving carbenicillin had mild template bleeding time prolongations of <13 min. Coagulation studies (prothrombin time, partial thromboplastin time, and thrombin time) were normal in all subjects, and blood salicylate levels were negative. Thus, in standard therapeutic doses, mezlocillin was less likely than carbenicillin to prolong the template bleeding time above normal (P = 0.04) and, when prolongation occurred with mezlocillin, it was mild. These data support the selective use of mezlocillin in patients at increased risk for bleeding and who require therapy with an antipseudomonal penicillin.

AB - Mezlocillin was compared with carbenicillin and 0.9% NaCl as placebo in a double-blind manner to determine its effect in vivo on hemostasis in normal volunteers. Eighteen subjects were randomized to receive mezlocillin, 4 g every 6 h; carbenicillin, 7.5 g every 6 h; or placebo, 50 ml every 6 h, each given for 20 intravenous doses unless the template bleeding time after 10 doses was >15 min. Template bleeding times were determined before the dose 1 and 1 h after doses 10 and 20. Five of six (83%) subjects receiving carbenicillin developed template bleeding time prolongation to >21 min, and two of six (33%) subjects receiving mezlocillin and one of six (17%) subjects receiving carbenicillin had mild template bleeding time prolongations of <13 min. Coagulation studies (prothrombin time, partial thromboplastin time, and thrombin time) were normal in all subjects, and blood salicylate levels were negative. Thus, in standard therapeutic doses, mezlocillin was less likely than carbenicillin to prolong the template bleeding time above normal (P = 0.04) and, when prolongation occurred with mezlocillin, it was mild. These data support the selective use of mezlocillin in patients at increased risk for bleeding and who require therapy with an antipseudomonal penicillin.

UR - http://www.scopus.com/inward/record.url?scp=0021343337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021343337&partnerID=8YFLogxK

U2 - 10.1128/AAC.25.2.153

DO - 10.1128/AAC.25.2.153

M3 - Article

C2 - 6712199

AN - SCOPUS:0021343337

VL - 25

SP - 153

EP - 156

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 2

ER -