Compensatory activation in fronto-parietal cortices among HIV-infected persons during a monetary decision-making task

Christina S. Meade, Daniella M. Cordero, Andrea Hobkirk, Brandon M. Metra, Nan Kuei Chen, Scott A. Huettel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

HIV infection can cause direct and indirect damage to the brain and is consistently associated with neurocognitive disorders, including impairments in decision-making capacities. The tendency to devalue rewards that are delayed (temporal discounting) is relevant to a range of health risk behaviors. Making choices about delayed rewards engages the executive control network of the brain, which has been found to be affected by HIV. In this case–control study of 18 HIV-positive and 17 HIV-negative adults, we examined the effects of HIV on brain activation during a temporal discounting task. Functional MRI (fMRI) data were collected while participants made choices between smaller, sooner rewards and larger, delayed rewards. Choices were individualized based on participants' unique discount functions, so each participant experienced hard (similarly valued), easy (disparately valued), and control choices. fMRI data were analyzed using a mixed-effects model to identify group-related differences associated with choice difficulty. While there was no difference between groups in behavioral performance, the HIV-positive group demonstrated significantly larger increases in activation within left parietal regions and bilateral prefrontal regions during easy trials and within the right prefrontal cortex and anterior cingulate during hard trials. Increasing activation within the prefrontal regions was associated with lower nadir CD4 cell count and risk-taking propensity. These results support the hypothesis that HIV infection can alter brain functioning in regions that support decision making, providing further evidence for HIV-associated compensatory activation within fronto-parietal cortices. A history of immunosuppression may contribute to these brain changes. Hum Brain Mapp 37:2455–2467, 2016.

Original languageEnglish (US)
Pages (from-to)2455-2467
Number of pages13
JournalHuman Brain Mapping
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2016

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Parietal Lobe
Decision Making
HIV
Reward
Brain
Risk-Taking
HIV Infections
Magnetic Resonance Imaging
Gyrus Cinguli
Executive Function
CD4 Lymphocyte Count
Prefrontal Cortex
Immunosuppression
Health

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Meade, Christina S. ; Cordero, Daniella M. ; Hobkirk, Andrea ; Metra, Brandon M. ; Chen, Nan Kuei ; Huettel, Scott A. / Compensatory activation in fronto-parietal cortices among HIV-infected persons during a monetary decision-making task. In: Human Brain Mapping. 2016 ; Vol. 37, No. 7. pp. 2455-2467.
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Compensatory activation in fronto-parietal cortices among HIV-infected persons during a monetary decision-making task. / Meade, Christina S.; Cordero, Daniella M.; Hobkirk, Andrea; Metra, Brandon M.; Chen, Nan Kuei; Huettel, Scott A.

In: Human Brain Mapping, Vol. 37, No. 7, 01.07.2016, p. 2455-2467.

Research output: Contribution to journalArticle

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