Abstract
Complement is activated during malaria infection, but there is little evidence that it benefits the host. On the contrary, growing evidence points to the central role of complement activation in the pathogenesis of complicated malaria. Recent evidence suggests a critical role for C5a and the membrane attack complex in the pathogenesis of cerebral malaria, and for C5a in the pathogenesis of placental malaria. In addition, erythrocytes of children with severe malarial anemia have increased deposition of C3b and decreased capacity to regulate complement activation, that probably increase their susceptibility to destruction by liver and splenic macrophages. These observations justify further investigation of the role of complement in malaria and the testing of complement inhibitors as adjunctive treatment for severe malaria.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 293-301 |
| Number of pages | 9 |
| Journal | Trends in Molecular Medicine |
| Volume | 20 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2014 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
Cite this
}
Complement activation in malaria : Friend or foe? / Biryukov, Sergei; Stoute, Jose.
In: Trends in Molecular Medicine, Vol. 20, No. 5, 01.01.2014, p. 293-301.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Complement activation in malaria
T2 - Friend or foe?
AU - Biryukov, Sergei
AU - Stoute, Jose
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Complement is activated during malaria infection, but there is little evidence that it benefits the host. On the contrary, growing evidence points to the central role of complement activation in the pathogenesis of complicated malaria. Recent evidence suggests a critical role for C5a and the membrane attack complex in the pathogenesis of cerebral malaria, and for C5a in the pathogenesis of placental malaria. In addition, erythrocytes of children with severe malarial anemia have increased deposition of C3b and decreased capacity to regulate complement activation, that probably increase their susceptibility to destruction by liver and splenic macrophages. These observations justify further investigation of the role of complement in malaria and the testing of complement inhibitors as adjunctive treatment for severe malaria.
AB - Complement is activated during malaria infection, but there is little evidence that it benefits the host. On the contrary, growing evidence points to the central role of complement activation in the pathogenesis of complicated malaria. Recent evidence suggests a critical role for C5a and the membrane attack complex in the pathogenesis of cerebral malaria, and for C5a in the pathogenesis of placental malaria. In addition, erythrocytes of children with severe malarial anemia have increased deposition of C3b and decreased capacity to regulate complement activation, that probably increase their susceptibility to destruction by liver and splenic macrophages. These observations justify further investigation of the role of complement in malaria and the testing of complement inhibitors as adjunctive treatment for severe malaria.
UR - http://www.scopus.com/inward/record.url?scp=84899623435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899623435&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2014.01.001
DO - 10.1016/j.molmed.2014.01.001
M3 - Review article
C2 - 24508275
AN - SCOPUS:84899623435
VL - 20
SP - 293
EP - 301
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 5
ER -