Complementation of class II A alleles in the immune response to (GluLysTyr) polymers

C. H. Lai, U. M. Babu, K. Matsunaga, Z. A. Nagy, Jan Klein, H. A. Turchin, P. H. Maurer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.

Original languageEnglish (US)
Pages (from-to)38-48
Number of pages11
JournalExperimental and Clinical Immunogenetics
Volume3
Issue number1
StatePublished - Dec 1 1986

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Free Association
Heterozygote
Haplotypes
Polymers
Alleles
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Lai, C. H., Babu, U. M., Matsunaga, K., Nagy, Z. A., Klein, J., Turchin, H. A., & Maurer, P. H. (1986). Complementation of class II A alleles in the immune response to (GluLysTyr) polymers. Experimental and Clinical Immunogenetics, 3(1), 38-48.
Lai, C. H. ; Babu, U. M. ; Matsunaga, K. ; Nagy, Z. A. ; Klein, Jan ; Turchin, H. A. ; Maurer, P. H. / Complementation of class II A alleles in the immune response to (GluLysTyr) polymers. In: Experimental and Clinical Immunogenetics. 1986 ; Vol. 3, No. 1. pp. 38-48.
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Lai, CH, Babu, UM, Matsunaga, K, Nagy, ZA, Klein, J, Turchin, HA & Maurer, PH 1986, 'Complementation of class II A alleles in the immune response to (GluLysTyr) polymers', Experimental and Clinical Immunogenetics, vol. 3, no. 1, pp. 38-48.

Complementation of class II A alleles in the immune response to (GluLysTyr) polymers. / Lai, C. H.; Babu, U. M.; Matsunaga, K.; Nagy, Z. A.; Klein, Jan; Turchin, H. A.; Maurer, P. H.

In: Experimental and Clinical Immunogenetics, Vol. 3, No. 1, 01.12.1986, p. 38-48.

Research output: Contribution to journalArticle

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AB - The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.

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Lai CH, Babu UM, Matsunaga K, Nagy ZA, Klein J, Turchin HA et al. Complementation of class II A alleles in the immune response to (GluLysTyr) polymers. Experimental and Clinical Immunogenetics. 1986 Dec 1;3(1):38-48.