The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.
|Original language||English (US)|
|Number of pages||11|
|Journal||Experimental and Clinical Immunogenetics|
|State||Published - Dec 1 1986|
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