Complementation of class II A alleles in the immune response to (GluLysTyr) polymers

C. H. Lai, U. M. Babu, K. Matsunaga, Z. A. Nagy, Jan Klein, H. A. Turchin, P. H. Maurer

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Abstract

The proliferative T cell responses to poly(GluLysTyr) (GLT) and poly(GLULysPhe) (GLPhe) are restricted by the EαEβ class II MHC molecule (E) in most responder strains. Some nonresponder strains that carry responder Eβ, but cannot express cell surface E molecules, can complement with other nonresponder strains that provide the missing Eα chain needed for the expression of E molecules and responsiveness to GLT and GLPhe. Here another type of complementation is described between two E-nonexpressor haplotypes, H-2(f) and H-2(s), which result in E-nonexpressor F1 hybrids, which are responders to GLT. The restriction element involved in this response is an A(f)/A(s) hybrid molecule. The data support the hypothesis that conformational determinants resulting from the free association of α and β chains in heterozygotes can increase the immune potential of the individual.

Original languageEnglish (US)
Pages (from-to)38-48
Number of pages11
JournalExperimental and Clinical Immunogenetics
Volume3
Issue number1
StatePublished - Dec 1 1986

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics
  • Genetics(clinical)

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    Lai, C. H., Babu, U. M., Matsunaga, K., Nagy, Z. A., Klein, J., Turchin, H. A., & Maurer, P. H. (1986). Complementation of class II A alleles in the immune response to (GluLysTyr) polymers. Experimental and Clinical Immunogenetics, 3(1), 38-48.