Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum

Mitchell S. Abrahamsen, Thomas J. Templeton, Shinichiro Enomoto, Juan E. Abrahante, Guan Zhu, Cheryl A. Lancto, Mingqi Deng, Chang Liu, Giovanni Widmer, Saul Tzipori, Gregory A. Buck, Ping Xu, Alan T. Bankier, Paul H. Dear, Bernard A. Konfortov, Helen F. Spriggs, Lakshminarayan Iyer, Vivek Anantharaman, L. Aravind, Vivek Kapur

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Abstract

The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalScience
Volume304
Issue number5669
DOIs
StatePublished - Apr 16 2004

All Science Journal Classification (ASJC) codes

  • General

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    Abrahamsen, M. S., Templeton, T. J., Enomoto, S., Abrahante, J. E., Zhu, G., Lancto, C. A., Deng, M., Liu, C., Widmer, G., Tzipori, S., Buck, G. A., Xu, P., Bankier, A. T., Dear, P. H., Konfortov, B. A., Spriggs, H. F., Iyer, L., Anantharaman, V., Aravind, L., & Kapur, V. (2004). Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum. Science, 304(5669), 441-445. https://doi.org/10.1126/science.1094786