Complete removal of load is detrimental to rotator cuff healing

Leesa M. Galatz, Nichole Charlton, Rosalina Das, H. Mike Kim, Necat Havlioglu, Stavros Thomopoulos

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Hypothesis: This study evaluated the effect of the mechanical environment on the healing rotator cuff by paralyzing the supraspinatus muscle in the operative shoulder of a rat model of rotator cuff injury and repair. Methods: Unilateral shoulders of rats underwent a supraspinatus injury and repair. Botulinum toxin A was used to paralyze the muscle after repair. Postoperatively, 1 group was immobilized and 1 group was allowed free range of motion. Saline-injected, casted rats were used as the control group. Repairs were evaluated histologically, geometrically, and biomechanically. Results: Specimens from the saline-injected rats had greater scar volume and cross-sectional area of the repair compared with the paralyzed groups. Structural properties were increased in the saline group compared with the paralyzed groups. Free range of motion (ie, uncasted group) resulted in modest improvements in biomechanical properties but did not obviate the effect of paralysis. Conclusions: Complete removal of load was detrimental to rotator cuff healing, especially when combined with immobilization. Level of evidence: Basic science study.

Original languageEnglish (US)
Pages (from-to)669-675
Number of pages7
JournalJournal of Shoulder and Elbow Surgery
Volume18
Issue number5
DOIs
StatePublished - Sep 1 2009

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Rotator Cuff
Articular Range of Motion
Paralysis
Muscles
Type A Botulinum Toxins
Immobilization
Cicatrix
Control Groups
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Galatz, Leesa M. ; Charlton, Nichole ; Das, Rosalina ; Kim, H. Mike ; Havlioglu, Necat ; Thomopoulos, Stavros. / Complete removal of load is detrimental to rotator cuff healing. In: Journal of Shoulder and Elbow Surgery. 2009 ; Vol. 18, No. 5. pp. 669-675.
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Galatz, LM, Charlton, N, Das, R, Kim, HM, Havlioglu, N & Thomopoulos, S 2009, 'Complete removal of load is detrimental to rotator cuff healing', Journal of Shoulder and Elbow Surgery, vol. 18, no. 5, pp. 669-675. https://doi.org/10.1016/j.jse.2009.02.016

Complete removal of load is detrimental to rotator cuff healing. / Galatz, Leesa M.; Charlton, Nichole; Das, Rosalina; Kim, H. Mike; Havlioglu, Necat; Thomopoulos, Stavros.

In: Journal of Shoulder and Elbow Surgery, Vol. 18, No. 5, 01.09.2009, p. 669-675.

Research output: Contribution to journalArticle

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AU - Charlton, Nichole

AU - Das, Rosalina

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AU - Thomopoulos, Stavros

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N2 - Hypothesis: This study evaluated the effect of the mechanical environment on the healing rotator cuff by paralyzing the supraspinatus muscle in the operative shoulder of a rat model of rotator cuff injury and repair. Methods: Unilateral shoulders of rats underwent a supraspinatus injury and repair. Botulinum toxin A was used to paralyze the muscle after repair. Postoperatively, 1 group was immobilized and 1 group was allowed free range of motion. Saline-injected, casted rats were used as the control group. Repairs were evaluated histologically, geometrically, and biomechanically. Results: Specimens from the saline-injected rats had greater scar volume and cross-sectional area of the repair compared with the paralyzed groups. Structural properties were increased in the saline group compared with the paralyzed groups. Free range of motion (ie, uncasted group) resulted in modest improvements in biomechanical properties but did not obviate the effect of paralysis. Conclusions: Complete removal of load was detrimental to rotator cuff healing, especially when combined with immobilization. Level of evidence: Basic science study.

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