Compliance with oral drug therapy in patients with hematologic malignancy

A. M. Levine, J. L. Richardson, G. Marks, K. Chan, J. Graham, J. N. Selser, C. Kishbaugh, D. R. Shelton, C. A. Johnson

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Compliance with oral self-administered allopurinol (daily medication) and prednisone (intermittent medication) as well as compliance with monthly scheduled clinic appointments were examined in 108 patients with newly diagnosed hematologic malignancy. Baseline levels of compliance (control group) were compared to results obtained after implementation of three intervention packages, whose aim was to increase compliance. The packages included combinations of education, home psychologic support and restructuring, and training in pill taking. A 24-hour profile of the two drugs and their metabolites was first determined. Serum samples were then obtained monthly over 6 months and analyzed for presence of the drugs. Control patients were fully compliant with allopurinol only 16.8% of the time. This rate increased significantly (44% to 48% of the time) for those who received any one of the intervention programs. With respect to prednisone, control patients were compliant 26.8% of the time, with no real improvement after interventions. Finally, self reports overestimated compliance by a factor of two when compared to drug analysis. The results indicated that full compliance with oral medications was remarkably low among our patients who have treatable and in some cases curable hematologic malignancy. However, compliance can be significantly improved by the use of various intervention packages.

Original languageEnglish (US)
Pages (from-to)1469-1476
Number of pages8
JournalJournal of Clinical Oncology
Volume5
Issue number9
DOIs
StatePublished - Jan 1 1987

Fingerprint

Hematologic Neoplasms
Compliance
Drug Therapy
Allopurinol
Prednisone
Pharmaceutical Preparations
Training Support
Self Report
Appointments and Schedules
Education
Control Groups
Serum

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Levine, A. M., Richardson, J. L., Marks, G., Chan, K., Graham, J., Selser, J. N., ... Johnson, C. A. (1987). Compliance with oral drug therapy in patients with hematologic malignancy. Journal of Clinical Oncology, 5(9), 1469-1476. https://doi.org/10.1200/JCO.1987.5.9.1469
Levine, A. M. ; Richardson, J. L. ; Marks, G. ; Chan, K. ; Graham, J. ; Selser, J. N. ; Kishbaugh, C. ; Shelton, D. R. ; Johnson, C. A. / Compliance with oral drug therapy in patients with hematologic malignancy. In: Journal of Clinical Oncology. 1987 ; Vol. 5, No. 9. pp. 1469-1476.
@article{bed5d86da1424813b364e0ffb2d9733c,
title = "Compliance with oral drug therapy in patients with hematologic malignancy",
abstract = "Compliance with oral self-administered allopurinol (daily medication) and prednisone (intermittent medication) as well as compliance with monthly scheduled clinic appointments were examined in 108 patients with newly diagnosed hematologic malignancy. Baseline levels of compliance (control group) were compared to results obtained after implementation of three intervention packages, whose aim was to increase compliance. The packages included combinations of education, home psychologic support and restructuring, and training in pill taking. A 24-hour profile of the two drugs and their metabolites was first determined. Serum samples were then obtained monthly over 6 months and analyzed for presence of the drugs. Control patients were fully compliant with allopurinol only 16.8{\%} of the time. This rate increased significantly (44{\%} to 48{\%} of the time) for those who received any one of the intervention programs. With respect to prednisone, control patients were compliant 26.8{\%} of the time, with no real improvement after interventions. Finally, self reports overestimated compliance by a factor of two when compared to drug analysis. The results indicated that full compliance with oral medications was remarkably low among our patients who have treatable and in some cases curable hematologic malignancy. However, compliance can be significantly improved by the use of various intervention packages.",
author = "Levine, {A. M.} and Richardson, {J. L.} and G. Marks and K. Chan and J. Graham and Selser, {J. N.} and C. Kishbaugh and Shelton, {D. R.} and Johnson, {C. A.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1200/JCO.1987.5.9.1469",
language = "English (US)",
volume = "5",
pages = "1469--1476",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "9",

}

Levine, AM, Richardson, JL, Marks, G, Chan, K, Graham, J, Selser, JN, Kishbaugh, C, Shelton, DR & Johnson, CA 1987, 'Compliance with oral drug therapy in patients with hematologic malignancy', Journal of Clinical Oncology, vol. 5, no. 9, pp. 1469-1476. https://doi.org/10.1200/JCO.1987.5.9.1469

Compliance with oral drug therapy in patients with hematologic malignancy. / Levine, A. M.; Richardson, J. L.; Marks, G.; Chan, K.; Graham, J.; Selser, J. N.; Kishbaugh, C.; Shelton, D. R.; Johnson, C. A.

In: Journal of Clinical Oncology, Vol. 5, No. 9, 01.01.1987, p. 1469-1476.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Compliance with oral drug therapy in patients with hematologic malignancy

AU - Levine, A. M.

AU - Richardson, J. L.

AU - Marks, G.

AU - Chan, K.

AU - Graham, J.

AU - Selser, J. N.

AU - Kishbaugh, C.

AU - Shelton, D. R.

AU - Johnson, C. A.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Compliance with oral self-administered allopurinol (daily medication) and prednisone (intermittent medication) as well as compliance with monthly scheduled clinic appointments were examined in 108 patients with newly diagnosed hematologic malignancy. Baseline levels of compliance (control group) were compared to results obtained after implementation of three intervention packages, whose aim was to increase compliance. The packages included combinations of education, home psychologic support and restructuring, and training in pill taking. A 24-hour profile of the two drugs and their metabolites was first determined. Serum samples were then obtained monthly over 6 months and analyzed for presence of the drugs. Control patients were fully compliant with allopurinol only 16.8% of the time. This rate increased significantly (44% to 48% of the time) for those who received any one of the intervention programs. With respect to prednisone, control patients were compliant 26.8% of the time, with no real improvement after interventions. Finally, self reports overestimated compliance by a factor of two when compared to drug analysis. The results indicated that full compliance with oral medications was remarkably low among our patients who have treatable and in some cases curable hematologic malignancy. However, compliance can be significantly improved by the use of various intervention packages.

AB - Compliance with oral self-administered allopurinol (daily medication) and prednisone (intermittent medication) as well as compliance with monthly scheduled clinic appointments were examined in 108 patients with newly diagnosed hematologic malignancy. Baseline levels of compliance (control group) were compared to results obtained after implementation of three intervention packages, whose aim was to increase compliance. The packages included combinations of education, home psychologic support and restructuring, and training in pill taking. A 24-hour profile of the two drugs and their metabolites was first determined. Serum samples were then obtained monthly over 6 months and analyzed for presence of the drugs. Control patients were fully compliant with allopurinol only 16.8% of the time. This rate increased significantly (44% to 48% of the time) for those who received any one of the intervention programs. With respect to prednisone, control patients were compliant 26.8% of the time, with no real improvement after interventions. Finally, self reports overestimated compliance by a factor of two when compared to drug analysis. The results indicated that full compliance with oral medications was remarkably low among our patients who have treatable and in some cases curable hematologic malignancy. However, compliance can be significantly improved by the use of various intervention packages.

UR - http://www.scopus.com/inward/record.url?scp=0023580351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023580351&partnerID=8YFLogxK

U2 - 10.1200/JCO.1987.5.9.1469

DO - 10.1200/JCO.1987.5.9.1469

M3 - Article

VL - 5

SP - 1469

EP - 1476

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 9

ER -

Levine AM, Richardson JL, Marks G, Chan K, Graham J, Selser JN et al. Compliance with oral drug therapy in patients with hematologic malignancy. Journal of Clinical Oncology. 1987 Jan 1;5(9):1469-1476. https://doi.org/10.1200/JCO.1987.5.9.1469