Complications of elastase-induced arterial saccular aneurysm in rabbits: Case reports and literature review

Jason S. Villano, Christine A. Boehm, Elizabeth L. Carney, Timothy Cooper

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Endoluminal infusion and incubation of elastase with or without collagenase into the rabbit common carotid artery is an established model of arterial saccular aneurysm. The model mimics naturally occurring human cerebral aneurysms in many ways, including histologic and morphologic characteristics, hemodynamic pressures, and shear stresses. However, complications have been associated with the model. Here, we report 2 complications: 1) the first known case of iatrogenic laryngeal hemiplegia in a rabbit; and 2) histopathologically confirmed iatrogenic hippocampal and cerebellar infarcts (stroke). Finally, we present and review data from current literature on the morbidity and mortality associated with this model.

Original languageEnglish (US)
Pages (from-to)480-486
Number of pages7
JournalComparative Medicine
Volume62
Issue number6
StatePublished - Dec 1 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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    Villano, J. S., Boehm, C. A., Carney, E. L., & Cooper, T. (2012). Complications of elastase-induced arterial saccular aneurysm in rabbits: Case reports and literature review. Comparative Medicine, 62(6), 480-486.