Complications of thoracic computed tomography-guided fiducial placement for the purpose of stereotactic body radiation therapy

Shadi Yousefi, Brian T. Collins, Cristina A. Reichner, Eric D. Anderson, Carlos Jamis-Dow, Gregory Gagnon, Shakun Malik, Blair Marshall, Thomas Chang, Filip Banovac

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58 Scopus citations

Abstract

PURPOSE: This study examined the complication rates associated with percutaneous fiducial placement for the purpose of stereotactic body radiation therapy of primary and metastatic lung neoplasms. PATIENTS AND METHODS: This is a retrospective review of computed tomography (CT) scans and follow-up chest radiographs of 48 consecutive patients who underwent CT-guided percutaneous fiducial placement. The effect of age, sex, number of fiducials placed, and performance of a concomitant biopsy on the complication rates were assessed. RESULTS: Of 48 patients with a total of 221 fiducials placed, 16 (33%) had a procedure-related pneumothorax. There was no significant difference in pneumothorax rate based on age (P = 0.16), sex (P > 0.99), and number of fiducials placed (P = 0.21). Overall, 6 of 48 patients (12.5%) required a thoracostomy tube. Performance of a concomitant core needle biopsy at the time of fiducial placement was associated with pneumothorax rates of 64% compared with 26% without biopsies (P = 0.03). Postprocedural CT demonstrated hemorrhage in 9 patients (19%). Two patients had hemoptysis; one required admission. Patients' age, sex, number of fiducials placed, and performance of concomitant biopsy had no statistically significant implications on parenchymal hemorrhage incidence. CONCLUSION: Approximately one third of the patients develop a pneumothorax during CT-guided fiducial placement. Most are asymptomatic and do not require a thoracostomy. A concurrent biopsy at the time of fiducial placement is associated with an increased risk of pneumothorax. Hemorrhage occurs but is usually clinically insignificant.

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalClinical Lung Cancer
Volume8
Issue number4
DOIs
StatePublished - Jan 2007

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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    Yousefi, S., Collins, B. T., Reichner, C. A., Anderson, E. D., Jamis-Dow, C., Gagnon, G., Malik, S., Marshall, B., Chang, T., & Banovac, F. (2007). Complications of thoracic computed tomography-guided fiducial placement for the purpose of stereotactic body radiation therapy. Clinical Lung Cancer, 8(4), 252-256. https://doi.org/10.3816/CLC.2007.n.002